Episode 378: Antidepressants - lots of useful data but many important questions remain

In episode 378, James, Tina and Mike go over the latest antidepressant meta-analysis from the Lancet. We talk about the fact that antidepressants do work, but importantly, what does “work” mean. Most importantly, we talk about what questions about antidepressants are not answered by this meta-analysis. At the end we put everything (to do with antidepressants) into its proper context.

Show notes

1) Effectiveness of antidepressants

BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k1073

2) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Lancet. 2018 Feb 20. pii: S0140-6736(17)32802-7. doi: 10.1016/S0140-6736(17)32802-7