Episode 439: Taking a hard look at the evidence: PDE5 inhibitors in erectile dysfunction

In episode 439, Mike and James invite Adrienne to take us through the impressively large amount of evidence for the PDE5 inhibitors for erectile dysfunction. We find that the NNTs are 2-3 for the not clearly defined endpoint of successful intercourse. There is a 20% absolute increase in adverse effects but almost no one stops using these medications because of these effects. Go figure.

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Taking a hard look at the evidence: Phosphodiesterase-5- inhibitors in erectile dysfunction