class	category	condition	improve	evidence	harm	total	taper	reduce	frequency	monitor			Evid Based Med August 2013	A practical guide to stopping medicines in older people	A practical guide to stopping medicines in older people	A practical guide to stopping medicines in older people
Lipid regulators	Statins	cholesterol	1	1	1	3	Y	25	2	"blood pressure, heart rate"						
		previous heart attack or stroke	2			2		50	4	constitipation						
	Niacin	cholesterol				0		10	2 to 4	insomnia						
	"Cholesterol other (ezetimibe, cholestyramine, colestipol)"	cholesterol	0			0				anxiety						
	Fibrates	cholesterol				0										
Antidepressants	SSRI	depression				0										
		chronic pain				0										
		anxiety 				0										
		obsessive compulsive disorder				0										
		insomnia				0										
	SNRI	depression				0										
		chronic pain				0										
		anxiety 				0										
		obsessive compulsive disorder				0										
		insomnia				0										
	TCA	depression				0										
		chronic pain				0										
		anxiety 				0										
		obsessive compulsive disorder				0										
		insomnia				0										
		smoking cessation				0										
	Depression other	depression				0										
Narcotics	Narcotics	pain				0										
Beta-blockers	Beta-blockers	blood pressure				0										
		heart failure				0										
		angina				0										
		arrhythmia				0										
		tremor				0										
		glaucoma				0										
		migraine				0										
		previous heart attack or stroke				0										
ACE inhibitors	ACE inhibitors	blood pressure				0										
		heart failure				0										
		previous heart attack or stroke				0										
		diabetic kidney				0										
Antidiabetes	Metformin	diabetes				0										
	Sulfonylureas	diabetes				0										
	Insulin	diabetes				0										
	Glitazones	diabetes				0										
	"Diabetes other(DPP4s, Acarbose, GLPs, Meglitinides)"	diabetes				0										
Hypertension	Hypertension other	blood pressure				0										
Respiratory agents	Beta-agonists	asthma				0										
		chronic obstructive lung disease				0										
	Inhaled steroids	asthma				0										
		chronic obstructive lung disease				0										
	Leukotriene antagonists	asthma				0										
		chronic obstructive lung disease				0										
	Anticholinergics	asthma				0										
		chronic obstructive lung disease				0										
Anti-ulcerants	H2 antagonists	heartburn/GERD				0										
		ulcer prevention				0										
	PPIs	heartburn/GERD				0										
		ulcer prevention				0										
	Sucralfate	ulcer prevention														
	Misoprostol	ulcer prevention														
Diuretics	Thiazides	blood pressure				0										
		heart failure				0										
	"Diuretics (Furosemide, Metolazone, Torsemide)"	blood pressure				0										
		heart failure				0										
	Aldosterone antagonists	blood pressure				0										
		heart failure				0										
Antiepileptics	"Epilepsy (Gabapentin,Phenytoin, Valproate, Carbamazepine, Others"	epilepsy				0										
		pain				0										
Tranquilizers	Benzodiazepines	anxiety 				0										
		panic disorder				0										
Thyroid	Thyroid	hypothyroid symptoms				0										
		prevention but no symptoms				0										
Calcium antagonists	Calcium antagonists	blood pressure				0										
		angina				0										
		arrhythmia				0										
Antirheumatics	NSAIDs	osteoarthritis				0										
		rheumatoid arthritis				0										
	Acetaminophen	osteoarthritis				0										
		rheumatoid arthritis				0										
	Biologics	rheumatoid arthritis				0										
Hormones	Estrogen/progesterone	menopausal symptoms (hot flashes etc)				0										
		"risk prevention (CV, bones)"				0										
	Testosterone	andropause symptoms (vitality etc)				0										
		risk prevention (CV other)				0										
Angiotensin 2 blockers	Angiotensin 2 blockers	blood pressure				0										
		heart failure				0										
Vitamins/supplements	Vitamins/supplements	actual vitamin deficiency				0										
		prevention vitamin deficiency				0										
Hypnotics/sedatives	Benzodiazepines	insomnia				0										
	Non-benzodiazepine sedatives	insomnia				0										
Anti-clotting	Warfarin	afib/valve				0										
	NOAC	afib/valve				0										
Anti-resorption	Bisphosphonates	osteoporosis				0										
	Raloxifene	osteoporosis				0										
	Osteoporosis other	osteoporosis				0										
Uric acid	Colchicine	gout				0										
	Xanthine oxidase inhibitors(allopurinol/febuxostat)	gout				0										
	Gout other	gout				0										
Urinary tract	Alpha-blockers	benign prostatic hyperplasia				0										
	5-alpha reductase inhibitors	benign prostatic hyperplasia				0										
	Incontinence	incontinence				0										
Corticosteroids	Corticosteroids	inflammatory conditions				0										
Cholinesterase inhibitors	Cholinesterase inhibitors	Alzheimer's				0										
Antipsychotics	First generation antipsychotics	agitation in dementia				0										
		schizophrenia				0										
		bipolar				0										
		depression				0										
	Second generation antipsychotics	agitation in dementia				0										
		schizophrenia				0										
		bipolar				0										
		depression				0										
Antimigraine	Triptans	migraine				0										
	Migraine other	migraine				0										
Nitrates	Nitrates	angina				0										
Digoxin	Digoxin	heart failure				0										
		arrhythmia				0										
Parkinson's	Parkinson's	Parkinson's				0										
Erectile dysfunction	Erectile dysfunction	erectile dysfunction				0										
IBD	IBD	inflammatory bowel disease				0										
Weight loss	Weight loss	weight loss				0										
ADHD	ADHD	ADHD				0										
Antihistamines	Antihistamines	allergies				0										
Antiarrhythmics	Antiarrhythmics	arrhythmia				0										
Gastrointestinal other	"Gastrointestinal other (antacids, domperidone, metoclopramide)"	heartburn/GERD				0										
Heparin	Heparin	clotting disorder				0										
Smoking cessation	Smoking cessation	smoking cessation				0										
	ASA	previous heart attack or stroke				0										
		osteoarthritis				0										
		rheumatoid arthritis				0										
		afib/valve				0										
Anticonstipation	Constipation	constipation				0										
Antidiarrhea	Diarrhea	diarrhea				0										
Antinausea	Nausea	nausea				0