Does this drug have the potential to improve symptoms	Does this drug have evidence that it reduces outcomes that matter to the patient	Potential for harm	Total Score	Taper	Reduce dose	Frequency	Monitor	Other issues to consider drug interactions		Taper	Taper	Approach 	MonitorClass	Drug Category	Indication	yes(0)/maybe(1)/no (2)	yes(0)/somewhat(1)/no(2)	lots(2)/some(1)/minimal or none (0)	0-6	y/n	%	every X weeks	Signs and symptoms			Evid Based Med August 2013	A practical guide to stopping medicines in older people	A practical guide to stopping medicines in older people	A practical guide to stopping medicines in older peopleLipid regulators	Statins	cholesterol	1	1	1	3	Y	25	2	"blood pressure, heart rate"							Statins	previous heart attack or stroke	2	0	1	3	Y	50	4	constitipation							Niacin	cholesterol	1	2	2	5	N	10	2 to 4	insomnia							"Cholesterol other (ezetimibe, cholestyramine, colestipol)"	cholesterol	0	1	1	2	Y	15	2	anxiety							Fibrates	cholesterol	1	0	0	1	Y	50	4	"blood pressure, heart rate"						Antidepressants	SSRI	depression	2	2	1	5	N	25	2 to 4	constitipation							SSRI	chronic pain	1	1	2	4	Y	50	2	insomnia							SSRI	anxiety 	0	0	1	1	Y	10	4	anxiety							SSRI	obsessive compulsive disorder	1	2	0	3	N	15	2 to 4	"blood pressure, heart rate"							SSRI	insomnia	2	1	1	4	Y	50	2	constitipation							SNRI	depression	1	0	2	3	Y	25	4	insomnia							SNRI	chronic pain	0	2	1	3	Y	50	2 to 4	anxiety							SNRI	anxiety 	1	1	0	2	N	10	2	"blood pressure, heart rate"							SNRI	obsessive compulsive disorder	2	0	1	3	Y	15	4	constitipation							SNRI	insomnia	1	2	2	5	Y	50	2 to 4	insomnia							TCA	depression	0	1	1	2	N	25	2	anxiety							TCA	chronic pain	1	0	0	1	Y	50	4	"blood pressure, heart rate"							TCA	anxiety 	2	2	1	5	Y	10	2 to 4	constitipation							TCA	obsessive compulsive disorder	1	1	2	4	N	15	2	insomnia							TCA	insomnia	0	0	1	1	Y	50	4	anxiety							TCA	smoking cessation	1	2	0	3	Y	25	2 to 4	"blood pressure, heart rate"							Depression other	depression	2	1	1	4	N	50	2	constitipation						Narcotics	Narcotics	pain	1	0	2	3	Y	10	4	insomnia						Beta-blockers	Beta-blockers	blood pressure	0	2	1	3	Y	15	2 to 4	anxiety-JM							Beta-blockers	heart failure	1	1	0	2	Y	50	2	"blood pressure, heart rate"							Beta-blockers	angina	2	0	1	3	N	25	4	constitipation							Beta-blockers	arrhythmia	1	2	2	5	Y	50	2 to 4	insomnia							Beta-blockers	tremor	0	1	1	2	Y	10	2	anxiety							Beta-blockers	glaucoma	1	0	0	1	N	15	4	"blood pressure, heart rate"							Beta-blockers	migraine	2	2	1	5	Y	50	2 to 4	constitipation							Beta-blockers	previous heart attack or stroke	1	1	2	4	Y	25	2	insomnia						ACE inhibitors	ACE inhibitors	blood pressure	0	0	1	1	N	50	4	anxiety							ACE inhibitors	heart failure	1	2	0	3	Y	10	2 to 4	"blood pressure, heart rate"							ACE inhibitors	previous heart attack or stroke	2	1	1	4	Y	15	2	constitipation							ACE inhibitors	diabetic kidney	1	0	2	3	N	50	4	insomnia						Antidiabetes	Metformin	diabetes	0	2	1	3	Y	25	2 to 4	anxiety							Sulfonylureas	diabetes	1	1	0	2	Y	50	2	"blood pressure, heart rate"							Insulin	diabetes	2	0	1	3	Y	10	4	constitipation							Glitazones	diabetes	1	2	2	5	N	15	2 to 4	insomnia							"Diabetes other(DPP4s, Acarbose, GLPs, Meglitinides)"	diabetes	0	1	1	2	Y	50	2	anxiety						Hypertension	Hypertension other	blood pressure	1	0	0	1	Y	25	4	"blood pressure, heart rate"						Respiratory agents	Beta-agonists	asthma	2	2	1	5	N	50	2 to 4	constitipation							Beta-agonists	chronic obstructive lung disease	1	1	2	4	Y	10	2	insomnia							Inhaled steroids	asthma	0	0	1	1	Y	15	4	anxiety							Inhaled steroids	chronic obstructive lung disease	1	2	0	3	N	50	2 to 4	"blood pressure, heart rate"							Leukotriene antagonists	asthma	2	1	1	4	Y	25	2	constitipation							Leukotriene antagonists	chronic obstructive lung disease	1	0	2	3	Y	50	4	insomnia							Anticholinergics	asthma	0	2	1	3	N	10	2 to 4	anxiety							Anticholinergics	chronic obstructive lung disease	1	1	0	2	Y	15	2	"blood pressure, heart rate"						Anti-ulcerants	H2 antagonists	heartburn/GERD	2	0	1	3	Y	50	4	constitipation							H2 antagonists	ulcer prevention	1	2	2	5	Y	25	2 to 4	insomnia							PPIs	heartburn/GERD	0	1	1	2	N	50	2	anxiety							PPIs	ulcer prevention	1	0	0	1	Y	10	4	"blood pressure, heart rate"							Sucralfate	ulcer prevention	2	2	1	1	Y	15	2 to 4	constitipation							Misoprostol	ulcer prevention	1	1	2	2	N	50	2	insomnia						Diuretics	Thiazides	blood pressure	0	0	1	1	Y	25	4	anxiety							Thiazides	heart failure	1	2	0	3	Y	50	2 to 4	"blood pressure, heart rate"							"Diuretics (Furosemide, Metolazone, Torsemide)"	blood pressure	2	1	1	4	N	10	2	constitipation							"Diuretics (Furosemide, Metolazone, Torsemide)"	heart failure	1	0	2	3	Y	15	4	insomnia							Aldosterone antagonists	blood pressure	0	2	1	3	Y	50	2 to 4	anxiety							Aldosterone antagonists	heart failure	1	1	0	2	N	25	2	"blood pressure, heart rate"						Antiepileptics	"Epilepsy (Gabapentin,Phenytoin, Valproate, Carbamazepine, Others"	epilepsy	2	0	1	3	Y	50	4	constitipation							"Epilepsy (Gabapentin,Phenytoin, Valproate, Carbamazepine, Others"	pain	1	2	2	5	Y	10	2 to 4	insomnia						Tranquilizers	Benzodiazepines	anxiety 	0	1	1	2	Y	15	2	anxiety							Benzodiazepines	panic disorder	1	0	0	1	N	50	4	"blood pressure, heart rate"						Thyroid	Thyroid	hypothyroid symptoms	2	2	1	5	Y	25	2 to 4	constitipation							Thyroid	prevention but no symptoms	1	1	2	4	Y	50	2	insomnia						Calcium antagonists	Calcium antagonists	blood pressure	0	0	1	1	N	10	4	anxiety							Calcium antagonists	angina	1	2	0	3	Y	15	2 to 4	"blood pressure, heart rate"							Calcium antagonists	arrhythmia	2	1	1	4	Y	50	2	constitipation						Antirheumatics	NSAIDs	osteoarthritis	1	0	2	3	N	25	4	insomnia							NSAIDs	rheumatoid arthritis	0	2	1	3	Y	50	2 to 4	anxiety							Acetaminophen	osteoarthritis	1	1	0	2	Y	10	2	"blood pressure, heart rate"							Acetaminophen	rheumatoid arthritis	2	0	1	3	N	15	4	constitipation							Biologics	rheumatoid arthritis	1	2	2	5	Y	50	2 to 4	insomnia						Hormones	Estrogen/progesterone	menopausal symptoms (hot flashes etc)	0	1	1	2	Y	25	2	anxiety							Estrogen/progesterone	"risk prevention (CV, bones)"	1	0	0	1	Y	50	4	"blood pressure, heart rate"							Testosterone	andropause symptoms (vitality etc)	2	2	1	5	N	10	2 to 4	constitipation							Testosterone	risk prevention (CV other)	1	1	2	4	Y	15	2	insomnia						Angiotensin 2 blockers	Angiotensin 2 blockers	blood pressure	0	0	1	1	Y	50	4	anxiety							Angiotensin 2 blockers	heart failure	1	2	0	3	N	25	2 to 4	"blood pressure, heart rate"						Vitamins/supplements	Vitamins/supplements	actual vitamin deficiency	2	1	1	4	Y	50	2	constitipation							Vitamins/supplements	prevention vitamin deficiency	1	0	2	3	Y	10	4	insomnia						Hypnotics/sedatives	Benzodiazepines	insomnia	0	2	1	3	N	15	2 to 4	anxiety							Non-benzodiazepine sedatives	insomnia	1	1	0	2	Y	50	2	"blood pressure, heart rate"						Anti-clotting	Warfarin	afib/valve	2	0	1	3	Y	25	4	constitipation							NOAC	afib/valve	1	2	2	5	N	50	2 to 4	insomnia						Anti-resorption	Bisphosphonates	osteoporosis	0	1	1	2	Y	10	2	anxiety							Raloxifene	osteoporosis	1	0	0	1	Y	15	4	"blood pressure, heart rate"							Osteoporosis other	osteoporosis	2	2	1	5	Y	50	2 to 4	constitipation						Uric acid	Colchicine	gout	1	1	2	4	N	25	2	insomnia							Xanthine oxidase inhibitors(allopurinol/febuxostat)	gout	0	0	1	1	Y	50	4	anxiety							Gout other	gout	1	2	0	3	Y	10	2 to 4	"blood pressure, heart rate"						Urinary tract	Alpha-blockers	benign prostatic hyperplasia	2	1	1	4	N	15	2	constitipation							5-alpha reductase inhibitors	benign prostatic hyperplasia	1	0	2	3	Y	50	4	insomnia							Incontinence	incontinence	0	2	1	3	Y	25	2 to 4	anxiety						Corticosteroids	Corticosteroids	inflammatory conditions	1	1	0	2	N	50	2	"blood pressure, heart rate"						Cholinesterase inhibitors	Cholinesterase inhibitors	Alzheimer's	2	0	1	3	Y	10	4	constitipation						Antipsychotics	First generation antipsychotics	agitation in dementia	1	2	2	5	Y	15	2 to 4	insomnia							First generation antipsychotics	schizophrenia	0	1	1	2	N	50	2	anxiety							First generation antipsychotics	bipolar	1	0	0	1	Y	25	4	"blood pressure, heart rate"							First generation antipsychotics	depression	2	2	1	5	Y	50	2 to 4	constitipation							Second generation antipsychotics	agitation in dementia	1	1	2	4	Y	10	2	insomnia							Second generation antipsychotics	schizophrenia	0	0	1	1	N	15	4	anxiety							Second generation antipsychotics	bipolar	1	2	0	3	Y	50	2 to 4	"blood pressure, heart rate"							Second generation antipsychotics	depression	2	1	1	4	Y	25	2	constitipation						Antimigraine	Triptans	migraine	1	0	2	3	N	50	4	insomnia							Migraine other	migraine	0	2	1	3	Y	10	2 to 4	anxiety						Nitrates	Nitrates	angina	1	1	0	2	Y	15	2	"blood pressure, heart rate"						Digoxin	Digoxin	heart failure	2	0	1	3	N	50	4	constitipation							Digoxin	arrhythmia	1	2	2	5	Y	25	2 to 4	insomnia						Parkinson's	Parkinson's	Parkinson's	0	1	1	2	Y	50	2	anxiety						Erectile dysfunction	Erectile dysfunction	erectile dysfunction	1	0	0	1	N	10	4	"blood pressure, heart rate"						IBD	IBD	inflammatory bowel disease	2	2	1	5	Y	15	2 to 4	constitipation						Weight loss	Weight loss	weight loss	1	1	2	4	Y	50	2	insomnia						ADHD	ADHD	ADHD	0	0	1	1	Y	25	4	anxiety						Antihistamines	Antihistamines	allergies	1	2	0	3	N	50	2 to 4	"blood pressure, heart rate"						Antiarrhythmics	Antiarrhythmics	arrhythmia	2	1	1	4	Y	10	2	constitipation						Gastrointestinal other	"Gastrointestinal other (antacids, domperidone, metoclopramide)"	heartburn/GERD	1	0	2	3	Y	15	4	insomnia						Heparin	Heparin	clotting disorder	0	2	1	3	N	50	2 to 4	anxiety						Smoking cessation	Smoking cessation	smoking cessation	1	1	0	2	Y	25	2	"blood pressure, heart rate"							ASA	previous heart attack or stroke	2	0	1	3	Y	50	4	constitipation							ASA	osteoarthritis	1	2	2	5	N	10	2 to 4	insomnia							ASA	rheumatoid arthritis	0	1	1	2	Y	15	2	anxiety							ASA	afib/valve	1	0	0	1	Y	50	4	"blood pressure, heart rate"						Anticonstipation	Constipation	constipation	2	2	1	5	N	10	2 to 4	constitipation						Antidiarrhea	Diarrhea	diarrhea	1	1	2	4	Y	15	2	insomnia						Antinausea	Nausea	nausea	0	0	1	1	Y	50	4	anxiety