In episode 326, Mike (with James just there for his charm) goes over three studies in the area of renal stones, testosterone, and sleep apnea and the outcome, as expected, can be considered nothing but PREMIUM.

Show notes

1) Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial 

Lancet 2015;386:341–49

2) Effects of Testosterone Treatment in Older Men

N Engl J Med 2016;374:611-24

3) CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea

N Engl J Med 2016;375:919-31

4) Laughing alongside the best of evidence: Family physicians change ideas about tools, knowledge, practice, and medicine

Can Fam Physician September 2016;62:744-47 

In episode 325, Mike and James continue their discussion about numbers and how to communicate risks. We discuss if people even want shared decisions and then if they do, what talk tools to use to facilitate that discussion.

Show notes

FRACTURES

If you know BMI – Canadian data from FRAX

If you know BMD – Canadian data from FRAX

Mayo Osteoporosis Decision Aid

CVD

CVD calculator

ATRIAL FIBRILLATION

SparcTool

Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence

Circ Cardiovasc Qual Outcomes. 2016 Aug 23. pii: CIRCOUTCOMES.116.002901

In episode 324, Mike and James start a discussion about why numbers and our ability to communicate risks, benefits and harms to patients is crucial in today’s health care environment. Unfortunately, we find that many of us struggle with these concepts.

Show notes

Slides

In episode 323, James and Mike go over two new studies that have looked at the risk of using LABAs in combination with inhaled corticosteroids in both adults and children. Bottom line – no increased risk, but also not a lot of benefit either.

Show notes

Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma

N Engl J Med 2016;375:840-849

Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone

N Engl J Med 2016;375:850-860

In episode 322, Mike and James go over a new Tools for Practice that looked at the use of a combination product that may reduce the risk of HIV. It definitely seems to work but adherence is the key.

Show notes

Tools for Practice

Pre-Exposure Prophylaxis (PrEP): Are you PrEP’d for the future of HIV prevention?

In episode 321, James and Mike discuss two interesting studies. One is on the duration of antibiotics for community-acquired pneumonia and the other about the impact of total knee replacement on the overall quality of life. Interestingly, the results of these studies were different although that may have been the fact that one was on pneumonia and the other on TKR.

Show notes

1) Duration of Antibiotic Treatment
in Community-Acquired Pneumonia
A Multicenter Randomized Clinical Trial

JAMA Intern Med. doi:10.1001/jamainternmed.2016.3633

2) A Randomized, Controlled Trial of Total Knee Replacement 

N Engl J Med 2015;373:1597-606

In episode 320, Mike and James PREMIUM out yet again and talk about 3 new diabetes publications that our listeners have asked us about.

Show notes

1) LEADER Study

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

N Engl J Med 2016; 375:311-22

2) Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome

N Engl J Med 2015; 373:2247-57

3) Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care

BMJ 2016;354:i3477

In episode 319, Mike and James begin questioning the number of questions they are having to answer but plough forward and talk about confidence intervals, anticoagulation bridging, hormone replacement and finally bring it all home with comments on DRE. 

Show notes

How confidence intervals become confusion intervals

BMC Medical Research Methodology 2013;13:134

In episode 318, Mike and James attempt to answer even more questions. We run the spectrum from steroid injections, to repeat bone density measurements, to vortioxetine, generic drugs, and sitagliptin. Bottom line – please stop going to industry sponsored CME.

Show notes

1) Generic drugs

Tools for Practice

2) My Studies

mystudies.org

In episode 317, James and Mike continue with their question and answering quest. We offer our spin on cardiovascular risk assessment, prostate screening, creatinine clearance and at the end leave our listeners questioning our podcast.

Show notes

1) Bridge Over Diagnosis – a parody of Bridge Over Troubled Water

2) Estimating Renal Function for Drug Dosing: Rewriting the Gospel?

CJHP 2008;2:138-43

3) Kidney calc