In episode 341, James and Mike talk about the long awaited trial of evolocumab that evaluated the impact it has on cardiovascular outcomes. Certainly not a homerun - maybe a very expensive full swing bunt with an error that leads to a single. 

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1) Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease 

In episode 340, Mike and James get all bent out of shape when they discuss the evidence around spinal manipulative therapy and low back pain. The evidence suggests no reliable effect for acute pain but the possibility of an effect for chronic pain. But any recommendations are a stretch because of the poor quality of the evidence.

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In episode 339, Mike and James talk about the evidence that has do with do with whether you need to use sterile gloves and saline for excisions and lacerations. The answer is that you should insert a suppository with the non-tapered end first.  Listen to the podcast and see how we come to that conclusion.

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1) Tools for practice

In episode 338, Tina, Mike and James go over the best available evidence around the treatment for recurrent vulvovaginal candidiasis and we find that we can reduce relapse with regular use of azole antifungals or we could just treat when symptoms occur – guess what, it’s all up to patient preference. Oh, and treating the partner makes no difference.

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In episode 337, Mike and James yet again go over even more studies that you really need to know about. We cover questions around duration of antibiotics for otitis media, NSAID cardiovascular safety and children with atopic dermatitis and the need for bathing before applying steroids. And the answers are yes, no and maybe, except on Tuesdays.

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In episode 336, James and Mike finish their review of clinical practice guidelines. We talk about how well clinicians and patients understand the benefits and harms of treatments and tests and then end with how the perfect clinical practice guideline should be written.

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In episode 335, James and Mike continue their review of clinical practice guidelines. We discuss who writes the guidelines and if they mention values and preferences. At the end we let everyone know about the upcoming 28th annual BSM course on April 7/8, 2017 in Vancouver.

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In episode 334, Mike and James present the real evidence around a fictional, or is he, Santa Claus. We give everyone an evidence-based present wrapped in a systematic review. We discuss if Santa makes us kinder, and – SPOILER ALERT – when do children stop believing in Santa and does finding out scar them emotionally for life. 

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