TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

The BS Medicine Podcast episodes are presented by James McCormack and Michael Allan. We try to promote healthy skepticism and critical thinking and most of the podcasts are presented in a case-based approach. We also try to inject some humour into the whole process to make the learning more interesting. Occasionally we have great guests like Mike Kolber, Tina Korownyk and Bruce Arroll help us out.

Most podcast episodes are available for free until they become archived after about 1-2 months. Every 4th episode or so is a “New Studies You Need to Know About” podcast and these will only be available to our Premium Podcast members. Premium members will also be able to listen to all archived episodes since episode #1.

Episode 492: PREMIUM – New data on footwear and salt substitutes

In episode 492, Mike and James delve into a couple of potentially practice-changing results. The first trial looked at the effect of different shoes for knee osteoarthritis. You might be surprised by the results. The second trial is the first ever look at a salt substitute and what it does, believe it or not, to cardiovascular events and death. Yeah! You might also be surprised by the results. Check out what was found in this PREMIUM podcast.

Show Notes

1) The Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms: A Randomized Trial

Ann Intern Med. 2021 Apr 174:462-71

2) Effect of Salt Substitution on Cardiovascular Events and Death

N Engl J Med 2021; 385:1067-1077 DOI: 10.1056/NEJMoa2105675

Episode 491: Keeping it Simple for Emergency Room Dyspepsia

In episode 491, Mike and James invite Mike Kolber to talk about Pink Ladies and White Knights. In medical terms we are referring to whether or not it makes sense to add lidocaine and antispasmodics to antacids in patients who present to an emergency room with dyspepsia. Please ignore the parts when both Mikes battle it out for a place at King Arthur’s Round Table and when one of them wears a pink dress for effect.

Show Notes

Tools for Practice

Keeping it Simple for Emergency Room Dyspepsia 

Episode 489: Mission Slimpossible – Semaglutide for weight loss

In episode 489, Mike and James invite Adrienne to go over the evidence for weight loss with semaglutide. We find the evidence shows that weight loss is on average roughly 10 kg over the effect of placebo, however this comes at the expense and inconvenience (injection) of the medication and roughly 25% of people (over placebo) will have GI adverse effects.

Show Notes

Tools for Practice

Mission Slimpossible: Semaglutide for weight loss

CFPCLearn

Episode 488: COVID-19 Vaccine Adverse Events

In episode 488, Mike and James invite Mike Kolber back again to chat about what the best evidence says around COVID vaccine adverse effects. We discuss all the numbers around common post-dose side effects, anaphylaxis, thrombotic thrombocytopenia and myocarditis.

Show Notes

Tools for Practice

COVID-19 Vaccine Adverse Events

Episode 487: Real World Evidence for COVID-19 Vaccines

In episode 487, Mike and James invite Mike Kolber in to chat about the real-world evidence we have for the COVID vaccine. We find the effectiveness of the COVID vaccines pretty much mirrors what the original clinical trials show. There is also effectiveness evidence the vaccine works for the variants of concern and we even have safety evidence in pregnancy.

Show Notes

Tools for Practice
Real World Evidence for COVID-19 Vaccines

Episode 486: Needle in a Pain-Stack – Acupuncture for Chronic Low Back Pain

In episode 486, Mike and James go over the evidence we have for acupuncture in chronic low back pain. We find out that some evidence shows acupuncture will improve chronic low back pain in one in 6 patients. However, the magnitude of the effect seen is importantly less when you look at trials that actually use a sham control or those that are of higher quality or longer duration.

Show Notes

Tools for Practice

Needle in a Pain-Stack: Acupuncture for Chronic Low Back Pain

CFPC Learn

Episode 485: Anti-inflammatories for the treatment of community-treated COVID

In episode 485, Mike and James go over a couple of COVID trials that show two different anti-inflammatories – colchicine and inhaled budesonide – seem to have an effect on reducing hospitalizations or urgent care visits.

Show Notes

1) Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial

Lancet Respir Med. 2021 May 27;S2213-2600(21)00222-8.doi: 10.1016/S2213-2600(21)00222-8.

2) Inhaled budesonide in the treatment of early COVID-19(STOIC): a phase 2, open-label, randomised controlled trial

Lancet Respir Med. 2021 Jul;9(7):763-772. doi: 10.1016/S2213-2600(21)00160-0.Epub 2021 Apr 9.

Episode 484: PREMIUM – Vitamin D for respiratory infections and overestimating diagnoses

In episode 484, Mike and James go PREMIUM on two topics that annoy them – Vitamin D and interpretation of tests. We find there is no value to using Vitamin D to prevent acute respiratory infections and that as health care providers we overestimate the probability of diagnoses before and after testing.

Show notes

1) Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials 

Lancet Diabetes Endocrinol 2021; 9: 276–92 

2) Accuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing 

JAMA Intern Med. doi:10.1001/jamainternmed.2021.0269 

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This will be a live-streamed course from Edmonton, AB. Registration Opens August 2021

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