In episode 357. Mike and James invite Adrienne to help us work through all the studies that have looked at using riboflavin to prevent migraines. Unfortunately, the impact of riboflavin on migraines is consistently inconsistent and most RCTs found no reduction in migraine frequency. At least we have evidence for low-dose propranolol and amitriptyline.

Show notes

In episode 356, Mike and James welcome Jamal Ramji to the podcast because we really needed to do something PREMIUM. We discuss a study of subclinical hypothyroidism and a low FODMAP diet for IBS. At the end we figure out that TSH is a no, but that the low FODMAP is a yes at least for 1 in 5-10 people.

Show notes

In episode 355, James and Mike finish delving into the issues around lab reporting and measurements. We finally get to some potential solutions (sort of) with how to deal with the variation seen around all lab values/measurements.

In episode 354, James and Mike continue to delve into the issues around lab reporting and measurements. In this part, we talk about the variation seen with blood pressure measurements, glucose and Vitamin D as further examples of what clinicians need to be aware. Having this insight should give you more confidence to interpret lab values, or just frustrate the heck out of you.

In episode 353, James and Mike continue to delve into the issues around lab reporting. In this part, we talk about the variation seen with every measurement. We talk about reference change values and what they mean for clinical practice. We use examples of bone density and cholesterol to explain some of the nuances and problems associated with test variance.

In episode 352, James and Mike start to delve into the issues around lab reporting and the numbers that are reported and what the numbers really mean. We talk about the highs and the lows and the variability associated with measurement and realize at the end that, while lab tests may have important variability, the quality of our podcasts never varies – which may or may not be a good thing.

In episode 351, Mike and James welcome Danielle and Joey to the podcast and they go all PREMIUM on us. The new dynamic duo go over studies from 2 important areas – O2 for COPD and bariatric surgery for diabetes. At the end of the podcast we realize that Mike and James are superfluous when it comes to the podcast quality and usefulness – sad!

Show notes

In episode 350, Mike and James talk about the evidence around sleep restriction. The evidence is fairly solid and the results typically suggest an impact greater than sleeping pills with sleep restriction improving sleep for one in every two to six patients compared to sleep hygiene alone.