In episode 444, James and Mike wade into the evidence quagmire around hydroxychloroquine and COVID-19.  The bottom line is the evidence will likely be different around the time you listen to the podcast. So listen quickly.

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1)Tools for Practice

In episode 443, James and Mike continue with Mike Kolber and we discuss the evidence around electronic cigarettes and their use for smoking cessation. Overall, the podcast ends up being smoking hot in so many ways.

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Tools for Practice

In episode 442, James and Mike welcome back Mike Kolber to discuss all the evidence around biosimilars. The issue is exactly the same one we have had for decades with the question around brand name versus generic medications. Tune in and find out the answer.

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Tools for Practice

In episode 441, James and Mike revisit the problem with guidelines. We talk about recent writings on the issues around guidelines. We discuss the main problems and believe it or not we give advice and suggestions for how to make them better.

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1) Health Affair

In episode 440, Mike and James yet again invite Adrienne to go over all the evidence for treating toenail onychomycosis.  We find that ~ 40% more people get better on oral treatments than on placebo. For topicals the number is closer to 10%. Topicals should likely only be used if there is <40% nail involvement.

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Tools For Practice

In episode 439, Mike and James invite Adrienne to take us through the impressively large amount of evidence for the PDE5 inhibitors for erectile dysfunction. We find that the NNTs are 2-3 for the not clearly defined endpoint of successful intercourse. There is a 20% absolute increase in adverse effects but almost no one stops using these medications because of these effects. Go figure.

In episode 438, Mike and James discuss 4 studies that likely could change what you are doing, or saying to your patients in your practice. Hip replacements – they last longer than you may think, vitamin D – bigger isn’t better, actinic keratosis – 5-FU is best, and weight loss really does treat T2DM. Check it out.

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In episode 437, Mike and James invite Joey Ton to help us work through all the evidence around Platelet-Rich Plasma (PRP) injections for tendinopathies. The best evidence for Achilles tendinopathy, lateral epicondylitis, and rotator cuff tendinopathy shows no difference in pain, function or return to sport when PRP is compared to dry needling or saline.

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