In episode 435, Mike and James unravel the evidence around thyroid testing. We talk about an approach to deal with the lack of research and the variation in the measurement of TSH and many other things. At the end we both complain of fatigue, dry skin, puffy eyes, anxiety and depression – and immediately get a TSH test.

Show notes

1) Tools for Practice

Helping physicians fatigued by TSH Screening and Subclinical Hypothyroidism

2) Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline

BMJ. 2019 May 14;365:l2006. doi: 10.1136/bmj.l2006

In episode 434, James and Mike discuss the Treat Stroke to Target trial where subjects were randomized to attain different LDL levels in patients experiencing a stroke or TIA. We talk about whether the results of this trial mean you need to measure LDL levels or just give more statin. Listen to find out.

Show notes

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

N Engl J Med. 2019 Nov 18. doi: 10.1056/NEJMoa1910355

In episode 433, Mike and James get all sweet on the latest diabetic trials from 2019. We provide the results, the critique and the context and we do it all with our usual level of charm and wit – which is by all accounts at a level similar to the size of the effect that many diabetes medications have on CVD events. 

Show notes

Diabetes trials synopsis