In episode 378, James, Tina and Mike go over the latest antidepressant meta-analysis from the Lancet. We talk about the fact that antidepressants do work, but importantly, what does “work” mean. Most importantly, we talk about what questions about antidepressants are not answered by this meta-analysis. At the end we put everything (to do with antidepressants) into its proper context.

Show notes

1) Effectiveness of antidepressants

BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k1073

2) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Lancet. 2018 Feb 20. pii: S0140-6736(17)32802-7. doi: 10.1016/S0140-6736(17)32802-7

In episode 377, Mike and James finally get to the end of looking at all the available cannabinoid evidence and we continue to discuss how the evidence could be used in the context of a shared-decision making process.

Show notes

Simplified guideline for prescribing medical cannabinoids in primary care 

Canadian Family Physician 2018;64:111-20

Cannabinoid short summary

Cannabinoid patient summary

In episode 376, Mike and James take all the best available evidence around cannabinoid use and put the evidence into the concept of a shared-decision making guideline. Shocking as it may seem, shared-decision making is rarely a part of most guidelines but we show how valuable it can be to keep this concept in focus when it comes to giving suggestions for the use of many treatments.

Show notes

Simplified guideline for prescribing medical cannabinoids in primary care 

Canadian Family Physician 2018;64:111-20

Cannabinoid short summary

Cannabinoid patient summary