TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 440: Putting the FUN in Fungi: Toenail onychomycosis treatments

In episode 440, Mike and James yet again invite Adrienne to go over all the evidence for treating toenail onychomycosis.  We find that ~ 40% more people get better on oral treatments than on placebo. For topicals the number is closer to 10%. Topicals should likely only be used if there is <40% nail involvement.

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Putting the FUN in Fungi: Toenail onychomycosis treatments

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Episode 439: Taking a hard look at the evidence: PDE5 inhibitors in erectile dysfunction

In episode 439, Mike and James invite Adrienne to take us through the impressively large amount of evidence for the PDE5 inhibitors for erectile dysfunction. We find that the NNTs are 2-3 for the not clearly defined endpoint of successful intercourse. There is a 20% absolute increase in adverse effects but almost no one stops using these medications because of these effects. Go figure.

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Taking a hard look at the evidence: Phosphodiesterase-5- inhibitors in erectile dysfunction

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