TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 98: Inhaled steroids, LABAs and much much more – breathing life into the evidence

In episode 98, James and Mike delve into the world of asthma and leave the audience breathless with anticipation. We discuss what you do if inhaled corticosteroids don’t work completely and the risk of using LABAs on their own. Close to the end of the podcast James develops an acute asthmatic attack and Mike ‘accidentally’ gives James the wrong direction to the emergency room.

Show notes

1) Children with asthma – after inhaled steroids – then what?

N Engl J Med 2010;362:975-85

2) LABAs with or without inhaled corticosteroids

Am J Med 2010;123:322-8

3) Tools for Practice – Long-Acting Beta-Agonist Inhalers in Asthma: Breathing Evidence into the Debate?

http://www.acfp.ca/docs09/ToolsforPracticeInfoforWebsiteDec142009.pdf

4) Short-acting beta-agonists and harm

N Engl J Med 1992;326:501-6

Lancet 1990;336:1391-6

Episode 97:New stuff that we found – MMR/autism, metformin, A1c and colchicine

In Episode 97, Mike and James present listeners with 4 ‘diamonds in the rough’ which should have an impact on practice, or at least get you trending towards a change. Information on MMR and autism, metformin and Vit B12, HbA1C not being zero, and low dose colchicine are presented with the usual clarity and profoundness listeners have come to expect from the podcast. At the end we refer people to the show notes to clear up all the misinformation presented.

Show notes

1) Autism

Tools for practice synopsis

Lancet 1998; 351: 637–41

Clin Pharmacol Ther 2007;82:756-9

PLoS ONE 2008;3: e3140

N Engl J Med 2002;347:1477-82

Lancet 1998;351:1327-8

Lancet 1999; 353: 2026–9

BMJ 2002;324:393–6

JAMA 2001;285:1183-5

BMJ 2001;322:460–3

Lancet 2004; 364: 963–9

JAMA 2003;290:1763-6

Pediatrics 2004;114;584-91

Pediatrics 2003;112;1039-48

CMAJ 2010;182:e199-200

BMJ 2010;340:c593

Lancet 2004;363:750

BMJ 2006;333:890–5

Pediatrics 2010;125;654-9

2) Metformin and viamin B12 deficiency

BMJ 2010;340:c2181

3) Diabetes cohort

Lancet 2010; 375: 481–89

4) Low dose colchicine

Arth Rheu 2010;62;1060–8

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