In episode 205, Mike and James continue with their discussion on the use of A1c levels in type-2 diabetes. We discuss the variability in the measurement of A1c and given this, how tricky it is to use the A1c once therapy has been started. We also discuss the magnitude of the vascular benefit of therapies that change A1c and come to the conclusion that with all this confusion “minimally disruptive medicine” seems to make a lot of sense.
1) The variability of the A1c test
2) Calculators for converting glucose to A1c and vice versa