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Episode 259: The periodic health exam gets examined

In episode 259, Mike and James start off a potential podcast trilogy on the evidence surrounding the periodic health exam. We start off by talking about what patient’s want, what do doctor’s think, the harms of screening and the overall evidence for the periodic health exam. At the end we realise the elements of the PHE need to be examined in detail so stay tuned.

Show notes


Episode 258: IMPROVE-IT – ezetimibe, what it does and doesn’t do

Episode 258: IMPROVE-IT – ezetimibe, what it does and doesn’t do 

In episode 258, James and Mike discuss the very recently released IMPROVE-IT study that was presented November 17th, 2014 at the AHA meeting. We discuss what was found and what wasn’t found and whether or not these results lend credence to the lipid hypothesis. We find that finally a drug used to change a surrogate marker actually appears to reduce cardiovascular events (we have had 20 negative trials in a row before this) but the magnitude is certainly not huge. We discuss the nuances of the results and hopefully put it into a reasonable perspective.

Show notes

1) A copy of the IMPROVE-IT slides from the AHA meeting  

Episode 257: PREMIUM – Coenzyme Q10, antibiotics and alopecia areata

In episode 257, Mike and James go PREMIUM yet again and discuss the latest RCTs on Coenzyme Q10 in heart failure, antibiotics in otitis media with effusion, treatment for community acquired pneumonia and steroids for alopecia areata. Bottom line – you don’t want to miss the premium experience.

Show notes

1) The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial

JACC Heart Fail. 2014 Sep 25. pii: S2213-1779

2) Effect of antimicrobial treatment of acute otitis media on the daily disappearance of middle ear effusion: a placebo-controlled trial.

JAMA Pediatr. 2014 Jul;168(7):635-41. doi: 10.1001/jamapediatrics.2013.5311.

3) β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia

JAMA Intern Med. 2014 Oct 6. doi: 10.1001/jamainternmed.2014.4887 

4) Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children – A Randomized Clinical Trial

JAMA Dermatol. 2014 Jan;150(1):47-50. doi: 10.1001/jamadermatol.2013.5764

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