TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

The BS Medicine Podcast episodes are presented by James McCormack and Michael Allan. We try to promote healthy skepticism and critical thinking and most of the podcasts are presented in a case-based approach. We also try to inject some humour into the whole process to make the learning more interesting. Occasionally we have great guests like Mike Kolber, Tina Korownyk and Bruce Arroll help us out.

Most podcast episodes are available for free until they become archived after about 1-2 months. Every 4th episode or so is a “New Studies You Need to Know About” podcast and these will only be available to our Premium Podcast members. Premium members will also be able to listen to all archived episodes since episode #1.

Episode 579: Oral Calcitonin Gene-related Peptide Antagonists: A painfully long name for the acute treatment of migraines

In episode 579, Mike and James invite Nicholas Dugré back to the podcast to talk about the evidence around the benefits and harms of a new class of medications for the acute treatment of episodic migraines. Ubrogepant is an oral calcitonin gene-related peptide antagonist. In this case, amazing as it may sound, there are triple the number of systematic reviews than there are RCTs. Nonetheless, we go over all the evidence and at the end of the podcast you’ll know what the world knows about these agents.

Show notes

Tools for Practice

Oral Calcitonin Gene-related Peptide Antagonists: A painfully long name for the acute treatment of migraines

Episode 578: Making a difference in indifference? Medications for apathy in dementia

In episode 578, Mike, James and Jennifer Potter try to answer the question, in patients with dementia, how safe and effective are stimulants, antidepressants, and antipsychotics for treating apathy? We look at the evidence for methylphenidate, antipsychotics, and antidepressants so tune in to find out if any of these treatments have any sort of effect in this very difficult to treat condition.

Show notes
Tools for Practice
Making a difference in indifference? Medications for apathy in dementia

Episode 577: Looking for Closure: Managing simple excisions or wounds efficiently

In episode 577, Mike and James invite Jennifer Young to join us to go over all the evidence around how best to close punch biopsies, lacerations and incisions. We go over all the evidence for sutures (absorbable/nonabsorbable), skin glue, and tape. We look at cosmesis, patient satisfaction, and infection rates so have a listen and find out what we found.

Show notes
Tools for Practice
Looking for Closure: Managing simple excisions or wounds efficiently

Episode 574: Any berry good solutions to preventing UTIs: Cranberries?

In episode 574, James and Mike invite Jennifer Young back to the podcast to help us yet again look at the evidence for cranberries and the prevention of UTI’s. Unfortunately, there is a problem with the evidence as there is a high risk-of-bias from potential publication bias, small studies, and unblinding. However, if we look past some of these biases, cranberry products might be worth a try. But have a listen and see what the evidence says.

Show notes
1) Tools for Practice
Any berry good solutions to preventing UTIs: Cranberries?
2) MAKING EVIDENCE MATTER for EVERYONE CONFERENCE
Vancouver
May 24/25, 2024

Episode 573: Overcoming Resistance: Antipsychotics for difficult to treat depression

In episode 573, James and Mike invite Jamie Falk back to the podcast to help us simplify all the evidence around using antipsychotics for difficult to treat depression. They do seem to “work”, but you really need to know the numbers around what “work” means. At the end of the podcast, you will!

Show notes
1) Tools for Practice
Overcoming Resistance: Antipsychotics for difficult to treat depression
2) MAKING EVIDENCE MATTER for EVERYONE CONFERENCE
Vancouver
May 24/25, 2024

Episode 572: Preventing RSV Infections in Infants

In episode 572, James and Mike invite Samantha Moe back to the podcast to go over the evidence around the safety and effectiveness of the monoclonal antibodies used to reduce the risk of respiratory syncytial virus (RSV) infections in infants. We go over all the numbers for hospitalizations and death so you can make evidence-informed decisions.

Show Notes
1) Tools for Practice
Preventing RSV Infections in Infants

2) MAKING EVIDENCE MATTER for EVERYONE CONFERENCE
Vancouver
May 24/25, 2024
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Episode 571: PREMIUM – Antibiotics and Lipids

In episode 571, James and Mike talk about 2 new papers – we learn what antibiotics we can use for community-acquired pneumonia and we also talk about the prevalence and management of dyslipidemia in Canadian primary care practices and find out who has this problem and who gets treated.

Show Notes
Identifying the Best Initial Oral Antibiotics for Adults with Community‐Acquired Pneumonia: A Network Meta‐Analysis
J Gen Intern Med. 2024 Feb 15.doi: 10.1007/s11606-024-08674-1.

Prevalence and management of dyslipidemia in primary care practices in Canada
Can Fam Physician. 2024 Mar;70(3):187-196.doi: 10.46747/cfp.7003187

Episode 570: Statistics made simple and relevant – we promise – PART III

In episode 570, James and Mike finish their trilogy on statistics. We take what we discussed in the previous podcasts and go through a couple of examples that will hopefully solidify what all the terms and numbers really mean.

Show Notes
1) Sensible Medicine
Doing statistics can be difficult but understanding them can be fairly simple
2) Analysis of 567,758 randomized controlled trials published over 30 years reveals trends in phrases used to discuss results that do not reach statistical significance
PLoS Biol 2022: e3001562. https:// doi.org/10.1371/journal.pbio.3001562

 

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The 2024 MEME Conference – May 24-25, 2024

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Making Evidence Matter For Everyone | May 24 & 25, 2024
From the clinicians who brought you the Best Science Medicine Course and the Meds Conference, as well as the BS Medicine Podcast and Tools for Practice

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THE NUTRITION PROPOSITION BOOK

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

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