Episode 15: Treating Depression: The Recent Sad News about Anti-Depressants
In episode 15 a guest assists us in addressing the evidence suggesting anti-depressants are not as effective as believed. We review some biases in the anti-depressant research including publication bias (how good studies are published more than bad studies). We discuss how the benefits of anti-depressants over placebo increase as the severity of depression worsens. James prompts us to explain the effectiveness of the medications; although we dodge, some vague commitments do manage to escape.
2) Another select report on the selective publication of selective serotonin reuptake inhibitors
3) Antidepressants have a clinically important effect above placebo only in patients with severe depression
5) In children, with antidepressants, the magnitude of benefit is unlikely sufficient to justify the harms