In episode 129, we get back to giving our listeners PREMIUM content and we end up spending the entire time talking about drugs that, in theory, make you pee – and you wonder why we call this a PREMIUM podcast. We discuss a synopsis of an old drug hydrochlorothiazide and then we discuss the most recent clinical trial of the new aldosterone antagonist eplerenone. The podcast comes to an abrupt end when, because of either the topic or the coffee, both Mike and James have to leave to leave to attend to more important matters.
1) Hydrochlorothiazide – what is the evidence for its use?
2) Eplerenone – EMPHASIS-HF study
3) Aldosterone antagonist systematic review