Episode 67: A clot, a clot, I want it not – secondary stroke prevention with antiplatelets
In episode 67, we address ischemic stroke of arterial origin and go over some core therapies (ASA, dipyridamole, clopidogrel and warfarin). We also discuss complications of anti-thrombotics and the options for patients with a GI bleed on ASA. Although Peter attempts to guide us through the maze of evidence, all three of us get lost and have trouble finding our way back. Mike rightly corrects James about one of his comments and James responds in a purely professional manner.
Show Notes
1) ASA post-stroke – low dose
ATTC 2009
2) Clopidogrel versus ASA
CAPRIE
3) ASA and clopidogrel versus clopidogrel
CHARISMA
MATCH
4) ASA versus warfarin post-stroke
WARSS
5) Dipyridamole plus ASA
ESPS-2
ESPRIT
PRoFESS
7) GI bleeding and ASA
PPI added to ASA versus clopidogrel alone
H. pylori eradication plus proton pump inhibitor versus H. pylori eradication alone
Clopidogrel plus a PPI – interaction or not
