TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 134: Antipsychotics – schizophrenia the drugs – part 3

In episode 134, we get into the nitty gritty of choosing a second drug for schizophrenia if the first one doesn’t work or is not tolerated. In general, it appears there is some evidence to favour clozapine over other agents but the difference isn’t great and as with virtually all of medicine one has to intermingle the available evidence with a good dose of art to make a beautiful therapeutic picture.   

Show notes

1) CATIE

N Engl J Med 2005;353:1209–23

2) CUtLASS 1

Arch Gen Psychiatry 2006;63:1079–87

3) A meta-analysis of the efficacy of second-generation antipsychotics 

Arch Gen Psychiatry 2003;60:553-64

2) Clozapine versus other atypical antipsychotics for schizophrenia

Cochrane library

3)Clozapine versus typical neuroleptic medication for schizophrenia

Cochrane library

4) CATIE – clozapine versus other agents who do not respond to prior atypical antipsychotic treatment 

Am J Psychiatry 2006;163:600–10

Listening to this episode is for premium podcast members only. If you already have a membership, login to your account. If you aren't yet a premium subscriber, sign up today!

Search

Upcoming Events

Practical Evidence for Informed Practice (PEIP) – October 22-23, 2021

This will be a live-streamed course from Edmonton, AB. Registration Opens August 2021

BS Medicine Podcast

BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

PEER Tools