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Episode 134: Antipsychotics – schizophrenia the drugs – part 3

In episode 134, we get into the nitty gritty of choosing a second drug for schizophrenia if the first one doesn’t work or is not tolerated. In general, it appears there is some evidence to favour clozapine over other agents but the difference isn’t great and as with virtually all of medicine one has to intermingle the available evidence with a good dose of art to make a beautiful therapeutic picture.   

Show notes


N Engl J Med 2005;353:1209–23

2) CUtLASS 1

Arch Gen Psychiatry 2006;63:1079–87

3) A meta-analysis of the efficacy of second-generation antipsychotics 

Arch Gen Psychiatry 2003;60:553-64

2) Clozapine versus other atypical antipsychotics for schizophrenia

Cochrane library

3)Clozapine versus typical neuroleptic medication for schizophrenia

Cochrane library

4) CATIE – clozapine versus other agents who do not respond to prior atypical antipsychotic treatment 

Am J Psychiatry 2006;163:600–10

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