TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 135: Antipsychotics – use in the elderly – part 4

In episode 135, Mike and James and Adil finally get to the end of their antipsychotic tetralogy as they tackle the especially difficult issue of the use of antipsychotics in the elderly. The problem is non-pharmacological treatments do very little, and one is left with having to decide whether or not to use drugs. We discuss the evidence of effectiveness (or lack thereof) of these drugs and the very real potential for harm. At the end, Adil makes both Mike and James agitated and he sedates them with a high dose of a very fine cognac. 

Show notes

1) Non-pharmacological interventions

Aging Ment Health 2009;13:512-20

2) Use of antipsychotics for psychosis of dementia

Int J Geriatr Psychiatry 2007;22:475-84

Psychother Psychosom 2007;76:213-8

Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003476. 

3) Adverse effects of the antipsychotics

JAMA 2005;294:1934-43

NEJM 2005;353:2335-41

Ann Intern Med 2007;146:775-86

4) DART-AD study – effect of stopping antipsychotics

Lancet Neurol 2009;8:151–7

PLoS Med 5(4):e76.doi:10.1371/journal.pmed.0050076

5) Tools for practice

What are the Risks and Benefits of Stopping Antipsychotics in the Elderly?

Listening to this episode is for premium podcast members only. If you already have a membership, login to your account. If you aren't yet a premium subscriber, sign up today!

Search

BIG ANNOUNCEMENTS

THE NUTRITION PROPOSITION BOOK HAS JUST BEEN RELEASED

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

THE MEME CONFERENCE – Making Evidence Matter For Everyone

May 27-28, 2022 in Vancouver, BC

Our annual primary care evidence-based conference is BACK. The MEME conference is happening May 27/28 live and virtual in beautiful Vancouver, BC. Sure hope you can join us.

REGISTER NOW

BS Medicine Podcast

BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

PEER Tools

Search

Recent Posts

Archives

Categories

Meta