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Episode 136: PREMIUM – A head-to-head comparison of ezetimibe and prunes

In episode 136, James and Mike once again raise the content bar level with the premium of all PREMIUM podcasts. We talk about a study that looked at the effect of ezetimibe plus simvastatin and we get a very clear answer but unfortunately the question that was asked was completely wrong. We then bring the podcast to a rising never ending crescendo by discussing a “pivotal” trial comparing psyllium to prunes in chronic constipation and low and behold the answer is extremely useful and relevant to day-to-day practice. 



Lancet 2011;377:2181-92

2) The PRUNE trial

Aliment Pharmacol Ther 2011;33:822–8

3) An Evidence-Based Approach to the Management of Chronic Constipation in North America

Am J Gastroenterol 2005;100 Suppl 1:S5-S21

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