TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 38: New trials you need to know about

In episode 38 we try to go over 8 new studies in one podcast but only get half-way there. We cover 2 inhaled anticholinergic studies, one new glucose lowering trial and the latest smoking cessation RCT. Mike and James wax poetically about a variety of issues and demonstrate clearly their well-honed technique of how not to stay foccussed, succint and to-the-point which explains why we only got to half the studies.

Show Notes

1) Inhaled anticholinergics – for better or worse?

Tiotropium given for 4 years on-top of existing therapy – no increase in mortality and fewer myocardial infarctions

N Engl J Med 2008;359:1543-54

Inhaled anticholinergics increases risk of cardiovascular death – but not total mortality

JAMA 2008;300:1439-1450

2) VADT – trial – the third study showing either no benefit or harm from aggressively lowering blood glucose – glycated hemoglobin level reduced from 8.4% to 6.9%

N Engl J Med 2009;360:129-39

3) Varenicline for smoking cessation Varenicline verus transdermal nicotine

Thorax 2008;63:717-24

Evidence showing 0.5 mg BID of varenicline is as effective as 1 mg BID

FDA document

Listening to this episode is for premium podcast members only. If you already have a membership, login to your account. If you aren't yet a premium subscriber, sign up today!




Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.


THE MEME CONFERENCE – Making Evidence Matter For Everyone

May 27-28, 2022 in Vancouver, BC

Our annual primary care evidence-based conference is BACK. The MEME conference is happening May 27/28 live and virtual in beautiful Vancouver, BC. Sure hope you can join us.


BS Medicine Podcast

BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

PEER Tools


Recent Posts