TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 38: New trials you need to know about

In episode 38 we try to go over 8 new studies in one podcast but only get half-way there. We cover 2 inhaled anticholinergic studies, one new glucose lowering trial and the latest smoking cessation RCT. Mike and James wax poetically about a variety of issues and demonstrate clearly their well-honed technique of how not to stay foccussed, succint and to-the-point which explains why we only got to half the studies.

Show Notes

1) Inhaled anticholinergics – for better or worse?

Tiotropium given for 4 years on-top of existing therapy – no increase in mortality and fewer myocardial infarctions

N Engl J Med 2008;359:1543-54

Inhaled anticholinergics increases risk of cardiovascular death – but not total mortality

JAMA 2008;300:1439-1450

2) VADT – trial – the third study showing either no benefit or harm from aggressively lowering blood glucose – glycated hemoglobin level reduced from 8.4% to 6.9%

N Engl J Med 2009;360:129-39

3) Varenicline for smoking cessation Varenicline verus transdermal nicotine

Thorax 2008;63:717-24

Evidence showing 0.5 mg BID of varenicline is as effective as 1 mg BID

FDA document

Listening to this episode is for premium podcast members only. If you already have a membership, login to your account. If you aren't yet a premium subscriber, sign up today!

Search

BS Medicine Podcast

MEME 2023 Conference May 12-13, 2023

Making Evidence Matter For Everyone | May 12 & 13, 2023
From the clinicians who brought you the Best Science Medicine Course and the Meds Conference, as well as the BS Medicine Podcast and Tools for Practice

hectalks.com

BIG ANNOUNCEMENT

THE NUTRITION PROPOSITION BOOK HAS JUST BEEN RELEASED

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

BedMed: The High Blood Pressure Study

This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)

PEER Tools

Search

Recent Posts

Archives

Categories

Meta