Episode 522: PREMIUM – Should we ignore expiry dates on medications?
In episode 522, James and Mike quickly go over 3 new COVID trials that give useful PREMIUM information. BUT then we quickly go SUPER PREMIUM with evidence around the shelf life of medications and we discuss why the expiry dates on medications in almost no circumstances represent the date when medications should no longer be used.
1) Secondary Attack Rates for Omicron and Delta Variants of SARS-CoV-2 in Norwegian Households
JAMA. 2022 Apr 26;327(16):1610-1611. doi: 10.1001/jama.2022.3780
2)Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19
N Engl J Med 2022 Aug 18;387(7):599-610
3) Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge
N Engl J Med 2022; 387:790-798
4) Determination of albuterol and montelukast post-expiry drug strength by HPLC
Heliyon. 2022 Aug 5;8(8):e10104. doi: 10.1016/j.heliyon.2022.e10104
5) A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates
J Pharm Biomed Anal. 2019 Mar 20;166:222-235. doi: 10.1016/j.jpba.2019.01.016