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Episode 62: Type 2 Diabetes – how sweet it isn’t – THE END

In episode 62, the eighth and final podcast in our tome on the treatment of type-2 diabetes, we talk about cholesterol and ASA. Statins have evidence of benefit, around 3-4% absolute risk reductions over 5 years, other drugs for cholesterol have little if any evidence of benefit, and there is evidence of no benefit from taking ASA. We come up with an overall synopsis; increase activity, eat good food, use metformin, then maybe sulfonylureas, thiazides/ACE inhibitors for BP, statins but don’t measure cholesterol, and no ASA. Both James and Mike collapse from exhaustion and leave the final word to Chris their producer.

Show Notes

1) Statin meta-analyses

Lancet 2008;371:117-25

Table of data

Another table of data

2) Fibric acid derivatives FIELD

Lancet 2005;366:1849-61

Fibrate meta-analysis

Arch Intern Med 2005;165:725-30

3) ASA – no benefit in diabetics

JAMA 2008;300:2134-41

BMJ 2008;337:a1840

Diabetes Care 2003;26:3264-72

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