In episode 337, Mike and James yet again go over even more studies that you really need to know about. We cover questions around duration of antibiotics for otitis media, NSAID cardiovascular safety and children with atopic dermatitis and the need for bathing before applying steroids. And the answers are yes, no and maybe, except on Tuesdays.

Show notes

1) Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children

N Engl J Med 2016;375:2446-56

JAMA Intern Med 2016;176:1257-65

2) Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

N Engl J Med 2016;375:2519-29

3) A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis

J Am Acad Dermatol 2016;75:306-11

In episode 336, James and Mike finish their review of clinical practice guidelines. We talk about how well clinicians and patients understand the benefits and harms of treatments and tests and then end with how the perfect clinical practice guideline should be written.

Show notes

See episode 333

In episode 335, James and Mike continue their review of clinical practice guidelines. We discuss who writes the guidelines and if they mention values and preferences. At the end we let everyone know about the upcoming 28th annual BSM course on April 7/8, 2017 in Vancouver.

Show notes

See Episode 333

In episode 334, Mike and James present the real evidence around a fictional, or is he, Santa Claus. We give everyone an evidence-based present wrapped in a systematic review. We discuss if Santa makes us kinder, and – SPOILER ALERT – when do children stop believing in Santa and does finding out scar them emotionally for life. 

Show notes

Tools for Practice

What’s in your Stocking: Evidence around Santa Claus

In episode 333, James and Mike do a review of what we know about clinical practice guidelines. We discuss how guidelines are graded and what would make them awesome – and then reality sets in, quickly followed by depression.

Show notes

Handout

In episode 332, James and Mike put a finishing touch on their upstanding erectile dysfunction discussion. We spend most of the podcast talking about treatments and options for ED and at the end we decide to never again be in the same room when talking about such a sensitive topic.

Show notes

See previous podcast

In episode 331, James and Mike talk about the ups and downs of erectile dysfunction. We take a penetrating look at the epidemiology and what initial assessments should be done – treatments will pop-up in the next podcast. Fortunately or unfortunately, we rarely raise our comments above what would be expected from 14 year-old boys.

Show notes

 Handout

In episode 330, Mike and James do a PREMIUM job of looking at 2 important new publications about medications for type 2 diabetes. We look at an RCT of semaglutide that actually shows a benefit. We then look at a very thorough systematic review/meta-analysis of all the studies and publications around T2DM since 1998. The results demonstrate very clearly that the evidence doesn’t really support what is being written in the diabetes clinical practice guidelines.

Show notes

1) SUSTAIN-6 

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

N Engl J Med 2016; 375:1834-44

2) Glycemic Control for Patients With Type 2 Diabetes Mellitus Our Evolving Faith in the Face of Evidence

Circ Cardiovasc Qual Outcomes. 2016;9:00-00. DOI: 10.1161/CIRCOUTCOMES.116.002901. 

In episode 329, Mike and James continue with their update on the treatment of dementia. We talk about prevention and how to figure out if an individual is getting a benefit from treatment. Bottom line, it is very tricky. We also talk about non-drug treatments and the latest new drug treatment.

Show notes

See Episode 328

In episode 328, Mike and James do an update of what is new for the treatment of dementia. We go over the scales used to assess dementia and then look at the latest trials for the commonly used drugs. Sadly, the treatments are still sorely limited.

Show notes

Handout