In episode 596, Mike and James talk in a PREMIUM way about three trials that used methotrexate for osteoarthritis and walking for back pain. Nothing miraculous but there seems to be an effect – so have a listen. Show Notes Pain Reduction With Oral Methotrexate in Knee Osteoarthritis: A Randomized, Placebo-Controlled Clinical Trial Ann Intern…

In episode 595, Mike and James invite Jennifer Young back to talk about the use of combined oral contraceptives for heavy menstrual bleeding (benign etiology) and see if they improve patient outcomes. They do! Have a listen to get all the numbers and see how they compare to using levonorgestrel-containing intrauterine devices or NSAIDs.

Show notes

Tools for Practice
1) How to Slow the Flow: Combined oral contraceptives
2) How to Slow the Flow: Tranexamic acid for heavy menstrual bleeding
3) How to Slow the Flow: Levonorgestrel intrauterine systems for heavy menstrual bleeding
4) How to Slow the Flow: NSAIDs for Heavy Menstrual Bleeding

In episode 594, Mike and James invite Samantha Moe back to talk about the use of the RSV vaccine in pregnancy. The only way to have an informed conversation around this vaccine is to know the numbers. If you listen to the whole podcast, you’ll get all the numbers available to date.

Show notes
Tools for Practice
1)Bumpin’ Up the Protection? RSV Vaccine in Pregnancy

2) Preventing RSV Infections in Infants

3) Preventing RSV in the elderly

In episode 593, Mike and James invite Samantha Moe back to talk about a newer agent for osteoporosis. So, if you want to know all the evidence for romosozumab, tune in and all will be revealed about the benefits and harms.

Show notes
1) Tools for Practice
Tony Romo-sozumab: Winning touchdown in osteoporosis or interception for the loss?

2) FRAX site for Canada

In episode 592, Mike and James invite Jennifer Young back to the podcast to review the evidence around the use of antidepressants in the challenging pain condition of fibromyalgia. We find there is an effect but, if you are going to help people make decisions, what you really need to know are the numbers for the benefits and harms around the use of these medications. We give you those, so have a listen.

Show notes
Tools for Practice
Pharm for Fibro: Can antidepressants ease the pain?

In episode 591, Mike and James invite Samantha Moe back to the podcast to review the evidence for using testosterone in older men. We talk about the impact testosterone supplementation has on sexual function, strength, fatigue, cognition, quality of life, and harms. There are 16 systematic reviews so we do have pretty good evidence – have a listen and see what the evidence says about what testosterone supplementation might do or not do.

Show notes
1) Tools for Practice
Testosterone supplementation for cis-gender men: Let’s (andro-)pause for a moment

In episode 590, Mike and James talk in a PREMIUM way about a new trial that looked at the question, does depression screening provide any benefit in primary care? We also go over a case-finding publication on screening for asthma/COPD. At the end we look at, does implementing guideline care improve outcomes for CKD? The…

In episode 589, Mike and James invite Jennifer Young back to the podcast again to talk about a topic that Mike absolutely loves – Vitamin D for everyone. Tune in to hear about all the latest, and the older, evidence. Do you agree we should remove the question mark from the podcast title?

Show notes
1) Tools for Practice
Vitamin D and Fracture Prevention: Not what it’s cracked up to be?

In episode 588, Mike and James invite Émélie Braschi back to the podcast to discuss another tricky area – insulin in type 2 diabetes and how to use it. Do we need to give it once a day, twice a day or maybe no times a day? Tune in to hear about all the evidence.

Show notes
1) Tools for Practice
Strategies for initiating insulin in type 2 diabetes

In episode 587, Mike and James invite Adrienne Lindblad back to the podcast to go over all the evidence we have for the oral GLP-1 weight loss medications. You know you are going to get lots of questions about these medications so tune in to find out all the numbers around the benefit and potential harms – and cost.

Show notes
1) Tools for Practice
Mission Slimpossible Part 2: Oral GLP-1 agonists for weight loss