In episode 524 – the first of a 2-part series about weight – James and Mike talk about why people wish to lose weight, the words we use to describe weight, the obesity paradox, all the cohort evidence around weight and mortality/cardiovascular disease/depression/osteoarthritis/fractures, and in a nice juxtaposition do it while eating rum and raisin ice cream – yes it is a thing.

Show Notes
1) The Nutrition Proposition
Book website

Amazon Link

2) In their own words: Topic analysis of the motivations and strategies of over 6,000 long‐term weight‐loss maintainers
Obesity (Silver Spring). 2022;30:751–7614)

3) Patients’ preferred terms for describing their excess weight: discussing obesity in clinical practice
Obesity (Silver Spring). 2012;20(1):147–50

In episode 523, James and Mike invite Jennifer Young to the podcast for the first time to help us go over all the evidence around diagnosing symptomatic uncomplicated urinary tract infections in adult women. We also delve into the “fun“ world of likelihood ratios – believe it or not, they are REALLY useful. So hang on to your hat!

Show Notes
Tools for Practice
Is booking an urgent UTI appointment the best sign of a UTI?

In episode 522, James and Mike quickly go over 3 new COVID trials that give useful PREMIUM information. BUT then we quickly go SUPER PREMIUM with evidence around the shelf life of medications and we discuss why the expiry dates on medications in almost no circumstances represent the date when medications should no longer be used.

Show Notes
1) Secondary Attack Rates for Omicron and Delta Variants of SARS-CoV-2 in Norwegian Households
JAMA. 2022 Apr 26;327(16):1610-1611. doi: 10.1001/jama.2022.3780
2)Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19
N Engl J Med 2022 Aug 18;387(7):599-610
3) Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge
N Engl J Med 2022; 387:790-798
4) Determination of albuterol and montelukast post-expiry drug strength by HPLC
Heliyon. 2022 Aug 5;8(8):e10104. doi: 10.1016/j.heliyon.2022.e10104
5) A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates
J Pharm Biomed Anal. 2019 Mar 20;166:222-235. doi: 10.1016/j.jpba.2019.01.016