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Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 502: CO-KID – vaccine for kids

In episode 502, James, Mike Kolber and Tony Nickonchuk get together to talk about the easy question (just kidding) of COVID vaccines for children and adolescents. We discuss the best evidence we could find around efficacy and adverse effects in these age groups and hopefully give enough context so that you go from murky to somewhat less cloudy as to what we know and don’t know about this topic.

Show Notes

1) Tools for Practice
CO-KID: Covid vaccine for kids

2) Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents
January 12, 2022 DOI: 10.1056/NEJMoa2117995

3) Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12–18 Years — United States, June–September 2021

4) Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12–18 Years — United States, July–December 2021

Episode 501: PREMIUM – Kangaroos, Vitamin D guidelines and delayed antibiotics

In episode 501, Mike and James get back to being PREMIUM by talking about the impressive effect of Kangaroo care – listen to find out what that is. We also talk about the problem with guidelines around Vitamin D and yet again more evidence for delayed antibiotics.

Show Notes

1) Kangaroo mother care to reduce morbidity and mortality in low birthweight infants
Cochrane Database Syst Rev 2016 Aug 23;2016(8):CD002771
2) Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight
N Engl J Med 2021;384:2028-38
3) Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors
Int J Clin Pract. 2021 Nov;75(11):e14805. doi: 10.1111/ijcp.14805. Epub 2021 Sep 15
4) Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial
Pediatrics. 2021 Mar;147(3):e20201323. doi: 10.1542/peds.2020-1323. Epub 2021 Feb 11.
5) Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis
BMJ 2021;373:n808

Episode 500: THANKS TO ALL OF YOU WHO LISTEN!!!

James and Mike celebrate their 500th, YIKES, podcast episode. You get to hear the entire intro song (Some People) written and recorded by Pete McCormack. We talk about the history of the podcast, thank a lot of people, and talk about the key messages and the philosophy we have tried to impart over the years. We then discuss a few cases that bring all these ideas into focus. THANKS SO MUCH FOR LISTENING and going on this journey with us. We have had a blast.

Show Notes

Pete McCormack’s Website
Tools for Practice
PEER Evidence

Episode 499: No Gain, No Pain? – Diet-induced weight loss for OA knee pain

In episode 499, James and Mike invite Tina back again to discuss the evidence we have for dieting to lose weight and the impact of that on osteoarthritis knee pain. Overall, there isn’t a lot of evidence but some observational data suggests a benefit Unfortunately the relatively small weight loss achieved from most diets in RCTs did not demonstrate a difference on OA pain.

Show Notes

Tools for Practice
No Gain, No Pain? – What is the effect of diet-induced weight loss on osteoarthritis-related knee pain?

Episode 497: The Nutrition Proposition – a teaser

In episode 497, James and Mike decide to go all in on the evidence around nutrition. We start out by going over how we try to actually figure out if a food is beneficial or harmful for you. And for nutrition is it ever tricky.

Show Notes

The Nutrition Proposition – Coming Soon – I hope

Episode 495: Medications in HFpEF: The Fail Trail

In episode 495, Mike and James invite Ricky back again to talk about the options (not a lot) we have for heart failure patients with preserved ejection fraction. Ricky goes over all the trials and helps put them into context.

Show Notes

Episode 494: Colchicine for your heart – it may not be just for gout

In episode 494, Mike and James invite Ricky Turgeon to talk about a potential new use for an old drug – colchicine. Ricky explains all the evidence we have for low-dose colchicine in people with a history of cardiovascular disease. We find out that colchicine reduces the risk of a cardiovascular event in a similar magnitude to statins – but will they be used as much as statins.? Find out what we think.

Show Notes

Tools for Practice

Cardiovascular prevention trials: Now calling colchicine to the stand

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