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Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 454: Exercise-induced osteoarthritis: Running into problems?

In episode 454, James and Mike invite Adam Keough to go through all the evidence around the impact of long-term running. We find out that recreational running likely does not increase the risk of developing osteoarthritis but high-level elite athletes may have an increased risk. Interestingly, exercise is one of the most effective treatments for reducing osteoarthritic pain. So as with most things in life – it’s all a balance.

Show notes 

Tools for Practice

Exercise-induced osteoarthritis: Running into problems?

Episode 453: Does baby know best? Baby-led weaning for transitioning to solid foods

In episode 453, James and Mike invite Jessica Kirkwood to go over all the evidence for transitioning infants to solid foods using a baby-led weaning approach versus traditional spoon feeding. Overall, it really didn’t make much difference which approach was used. But listen to hear us take a bite out of all the nuances and context.

Show notes 

Tools for Practice

 “Does baby know best?”: Benefits and harms of baby-led weaning for transitioning to solid foods

Episode 452: Once upon a time in diabetes land – squirrel!

In episode 452, James and Mike go over 2 recent publications which encapsulate all the important evidence around type 2 diabetes. We talk about the misdirection that occurs with T2DM evidence versus what we do in practice. We now have all the evidence and we know what these medications do or don’t do to important clinical endpoints. Could we please use this information when we treat T2DM.

Show notes 

Penn & Teller Give a Lesson in Misdirection Using a Vanishing Chicken

1) Comparative Effectiveness of Glucose-Lowering Drugs for

Type 2 Diabetes – A Systematic Review and Network Meta-analysis

Ann Intern Med. 2020 Jun 30.  doi: 10.7326/M20-0864

2) Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map

Lancet Diabetes Endocrinol. 2020 Mar;8(3):192-205

Episode 450: Osteoarthritis – all the evidence for all the treatments – PART II

In episode 450 Mike and James continue, with Danielle and Joey, going over our osteoarthritis systematic review. We talk in detail about all the evidence around oral NSAIDs, glucosamine, topical NSAIDs, chondroitin, viscosupplementation, oral opioids, acetaminophen. And now you know all the numbers.

Show notes 

PEER Umbrella Systematic Review of Systematic Reviews: Management of Osteoarthritis in Primary Care

Can Fam Phy 2020 Mar;66(3):e89-e98

Episode 449: Osteoarthritis – all the evidence for all the treatments

In episode 449, Mike and James invite Danielle Perry and Joey Ton to go over our osteoarthritis systematic review. We talk about all the evidence around exercise, steroid injections, SNRIs, oral NSAIDs, glucosamine, topical NSAIDs, chondroitin, viscosupplementation, oral opioids, acetaminophen. In fact, the magnitude of benefit is exactly in this order – exercise highest, acetaminophen lowest.

Show notes 

PEER Umbrella Systematic Review of Systematic Reviews: Management of Osteoarthritis in Primary Care

Can Fam Phy 2020 Mar;66(3):e89-e98.

Episode 448: Unmasking the evidence around masks for healthcare workers

In episode 448, Mike and James go over all the evidence around masks for preventing viral respiratory infections in healthcare workers. We find that surgical masks and N95 masks provide similar protection against viral infections. Unfortunately we have no evidence for COVID-19.

Show notes 

Tools for Practice

Unmasking the evidence around masks for healthcare workers

COVID Webinar

May 7

The COVID-19 Pivot: Rapid evidence reviews with the PEER team

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Making Evidence Matter For Everyone | May 9-10, 2025
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THE NUTRITION PROPOSITION BOOK

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

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