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Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 11: Taking the Pressure off: Other Drugs

In our 11th episode, we discuss the laundry list of the remaining hypertensive medications and their evidence. The issue of blood pressure as a surrogate marker is discussed and we encourage clinicians to focus on hypertensive agents that effect patient oriented outcomes. While the evidence is reasonable for Ca+ Blocker, we put Beta-blockers low down (and Atenolol off) the list with Alpha-blockers and a few others.We have few laughs along the way, primarily at our lack of humor.

Show Notes

1) Atenolol no better than placebo and other drugs are better than atenolol in reducing cardiovascular outcomes in patents with high blood pressure

Lancet 2004;364:1684–9

2) Beta-blockers do appear to increase the chance of developing diabetes

Am J Cardiol 2007;100:1254–62

3) A debate on using or not using betablockers for high blood pressure

Can Fam Physician 2007;53:614-7

4) ALLHAT – the problem with alpha-blockers

JAMA 2000;283:1967-75

5) Data for felodipine and cardiovascular events in patients with high blood pressure

Lancet 1998;351:1755-62

6) Use of low-dose spironolactone in “resistant” hypertension

Amer J Hyper 2003;16:925–30

7) Effect of spironolactone on albuminuria

Diabetes Care 2005;28:2106–12

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