Episode 110: Even more, questions, questions and more questions
In episode 110, in this final episode of the year James and Mike attempt to answer even more questions. They discuss the benefits and harms of using atypical antipsychotics in the elderly and decide that ‘microdoses’ is the correct answer. They get into a heated debate on the issue of the interaction with PPIs and clopidogrel and at the end both agree on the answer which is “Yes, but only on a Tuesday”. We finish off with a rousing discussion on the grapefruit/felodipine interaction and realise that neither of us like grapefruit so who cares. We both wish you and your family a Happy Holidays.
1) Data on benefit
Psychother Psychosom 2007;76:213-8
Cochrane Library 2006:CD003476
2) Data on harm
Atypical meta-analysis (of trials not designed to assess harm)
Cohort of conventional vs atypical
3) Actual RCT to assess risk benefit of withdrawal of antipsychotics
Lancet Neurol 2009;8:151–57
PLoS Med 5(4): e76.doi:10.1371/journal.pmed.0050076
4) One page summary of risks/benefits of anti-psychotics:
See Tools for Practice Website: http://www.acfp.ca/tfp_original.php
Specific reference: http://www.acfp.ca/docs10/Antipsychotics%20in%20Elderly%20_2_.pdf
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