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Episode 115: PREMIUM – Honey, should you shoot the NSAIDs?

In episode 115, Mike and James, in yet another stellar PREMIUM performance, provide the listening audience with the definitive answer on the cardiovascular risks associated with the NSAIDs. They then bring in a guest (Winnie-the-Pooh) to discuss in a sweet fashion whether or not there are any benefits from using honey for cough in children. At the end we are unable to recommend or not recommend honey, and so uncharacteristically Winnie-the Pooh bites both James and Mike and they end up on NSAIDs for the pain. 

Show notes

1) Cardiovascular safety of NSAIDs – or lack thereof

BMJ 2011; 342:c7086 doi: 10.1136/bmj.c7086

2) Acetaminophen/paracetamol

Causes liver damage and is “bad”

BMJ 2010; 341:c6764 doi: 10.1136/bmj.c6764

Hang-on, is it really bad or is it really safe? – and just how do you define narrow therapeutic ratio?

BMJ 2011; 2011; 342:d625 doi: 10.1136/bmj.d625 

“Other than citing a narrow therapeutic index, defined by the FDA as exceeding the daily 4,000 mg recommended maximum dose, between the therapeutic and toxic doses of acetaminophen, the FDA did not present any evidence upon which to validate their recommendation to reduce the daily dose from 4,000 to 3,250 mg”

Clin Toxicol 2009;47:784-9

2) Honey and cough in children 

J Alt Compl  Med 2010;16:787-93

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