TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 13: Butt-Out:Silencing “The Smoking Gun” in Health

In our 13th episode, we discuss smoking cessation. We present the impressive benefits in hard outcomes when people stop smoking. We then go through the list of interventions, from brief advice to the pharmaceutical options of nicotine replacement, two anti-depressants (Buproprion or Nortiriptyline) and the newest agent, Varenicline. Dosing, cessation rates and adverse events are reviewed (for medications, not cigarettes: that dose is zero).

Show Notes

1) Intensive smoking cessation intervention reduces mortality in high-risk smokers with cardiovascular disease

Chest 2007; 131: 446–52.

2) Listening empathetically and asking if they are ready to quit smoking

Silagy C, Ketteridge S. The effectiveness of physician advice to aid smoking cessation. Cochrane Database of Systematic Reviews 1998. Issue 2

3) Bupropion at a dose of 150 mg daily works as well as 300 mg daily

New Engl J Med 1997; 337:1195-202

4) Nortriptyline and bupropion for smoking cessation

Antidepressants for smoking cessation. Cochrane Database of Systematic Reviews 2007, Issue 1

5) Varenicline for smoking cessation

Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews 2008. Issue 3

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