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Episode 163: How to analyse a meta-analysis and at the end not need analysis – PART II

In episode 163, Mike and James race to the end of their in-depth look at critical appraisal and as they get to the end their final kick is at some of the problems seen with meta-analyses. We discuss examples of how meta-analyses sometime go wrong and we do our best to make them right – with varying degrees of success.

Show notes

1) Glucose lowering meta-analysis

Ann Intern Med 2009;151:394-403

2) Beta-blocker meta-analysis

Lancet 2005;366:1545–53

3) PSA screening

BMJ 2010;341:c4543 doi:10.1136/bmj.c4543

3) Statin meta-analyses on mortality effect in primary prevention 

BMJ 2009;338:b2376

RR 0.88 (0.81-0.96) 

Arch Intern Med 2010;170:1024-31

RR 0.91 (0.83-1.01)

Arch Intern Med 2005;165:725-30

RR 0.86 (0.76 -0.99) 

Arch Intern Med 2006;166:2307-13

RR 0.92 (0.84-1.01) 

J Am Coll Cardiol 2008;52:1769-81

RR 0.93 (0.87-0.99)

4) Back pain meta-analysis

Cochrane CD000335

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