Episode 169: Answering questions then questioning the answers

In episode 169, Mike and James get back to listener questions. Our listeners lead us down the garden path and we end up talking about bladder irritants, riboflavin for migraine prophylaxis, placebo, and as always low doses. Mike rebels by taking a high dose of obecalp which leads to some very strange side effects.

Show notes

1) Is caffeine a bladder irritant?

Urol Ann 2011:3:14-8

JAMA 2004;291:986

2) Riboflavin in migraine prophylaxis

Neurology 1998;50:466-70

Headache 2004;44:885-90

Cephalgia 2010;30:1426-34

J Child Neurol 2008;23:1300-4

3) Tools for practice

Are antihypertensive medications effective for migraine prophylaxis?

Antidepressants for preventing headaches: Which work and how well?

4) Placebo effect 

Cochrane library CD003974 

5) Low dose

CMAJ 2011;183:65–9