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Episode 194: The evidence for Vitamin D and folic acid for depression is not all that depressing

In episode 194, Mike and James invite our good friend and colleague David Gardner to layout the evidence for folic acid and Vitamin D for depression. Because there isn’t a lot of definitive evidence we discuss how to make recommendations in the face of limited evidence. We decide that decisions often come down to the chance of harm and what other alternatives are available. At the end, Mike and David decide to take Vitamin D and folic acid just to deal with all the snow they are under. James just goes outside in the sun and gardens.

Show notes

1) Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical Guidelines for the Management of Major Depressive Disorder in Adults

J Aff Disorders 2009;117:S1–S64

2) Enhancement of fluoxetine with folic acid

J Affect Disord 2000;60:121-30 

3) Folic acid with fluoxetine

Neuroimmunomodulation 2008;15:145-52

4) Methylfolate and depression

Lancet 1990;336:392-5

5) L-methylfolate for depression

Am J Psychiatry 2012;169:1267-74

6) Vitamin D as adjunctive therapy to fluoxetine

Aust N Z J Psychiatry 0004867412465022 2012

7) Medication Info Share

8) Effect size illustrator

 

 

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11th Annual PEIP Conference October 21-22, 2022

Practical Evidence for Informed Practice Conference | October 21 & 22, 2022
Led by the team that brings you Tools for Practice, the Practical Evidence for
Informed Practice (PEIP) Conference brings together clinical leaders to speak on
the latest findings that can affect how you practice.

www.peipconference.ca

BIG ANNOUNCEMENTS

THE NUTRITION PROPOSITION BOOK HAS JUST BEEN RELEASED

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

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