TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 216: Questions that lead to questions and then more questions – Part IV

In episode 216, Mike and James finally get to the last of the listener questions. We discuss the numbers around the pneumococcal and influenza vaccines, metformin and contraindications, the timing of antihypertensives, and stuff for osteoporosis. Ironically we end with the question “does any of this mean anything in the grand scheme of things?” and we design a metaphorical RCT to answer that question.

Show notes

1) Metformin and harm

Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review

BMJ 2007;335:497

2) Metformin’s contraindications should be contraindicated

CMAJ 2005;173:502-4

2) MAPEC study

Chronobiol Int 2010;27:1629-51

3) Tools for Practice

Does calcium (Ca+) supplementation contribute to increased risk of myocardial infarction (MI) and other cardiovascular disease (CVD)?

4) CVD risk calculator

http://bestsciencemedicine.com/chd

Listening to this episode is for premium podcast members only. If you already have a membership, login to your account. If you aren't yet a premium subscriber, sign up today!

Search

BS Medicine Podcast

The 2026 MEME Conference – May 8-9, 2026

REGISTRATION IN JANUARY 2026

Making Evidence Matter For Everyone | May 8-9, 2026
From the clinicians who brought you the Best Science Medicine Course and the Meds Conference, as well as the BS Medicine Podcast and Tools for Practice

hectalks.com

PEER Tools

BIG ANNOUNCEMENT

THE NUTRITION PROPOSITION BOOK

Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.

 

Search

Recent Posts

Archives

Categories

Meta