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Episode 65: A clot, a clot, I want it not – primary prevention with antiplatelets

In episode 65, we start back at it with a discussion of using antiplatelets to decrease the chance of MIs and strokes. In this podcast, we cover the whole primary prevention aspect of these agents and we bring in our good friend and colleague Peter Loewen to help us with the numbers. Mike claims he, as a family doctor, is usually able to make a diagnosis of gender in his patients but refuses to do so in James’ case.

Show Notes

1) Primary Prevention with ASA (women and men)

JAMA 2006;295:306-13

ATTC 2009

Lancet 2009;373:1849–60

2) ASA in Type II diabetics (primary prevention)


BMJ 2008;337:a1840

JPAD study

JAMA 2008;300:2134-41

PPP study

Diabetes Care 2003;26:3264-72

Canadian Diabetes Guideline (specifically, ASA)

Can J Diabet 2008;32:S102-06

3) Adding Clopidogrel to ASA in primary Prevention

CHARISMA Study (primary prevention sub-group)

NEJM 2006;354:1706-17

4) Peripheral vascular disease



Lancet 1996;348:1329-39

5) Peter Loewen


Pharmacotherapy for ischemic stroke prevention

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