TEC: Evidence Based Therapeutics
Therapeutics Education Collaboration
Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 74: Vitamin A, B, C, NOT D, and E – not all letters are created equal

In episode 74, Mike (Bert) and James (Ernie), along with Tina (Betty Lou) continue their stroll down medical Sesame Street and take a look at the evidence behind Vitamins (Letters) A,B,C, and E. Lo and behold, they find that not all letters are created equal and some are even quite bad. At the end, both Mike and James join the Cookie Monster for some Vitamin enriched (just D that is) treats and, they get Tina to pay.

Show notes

1) Tools for Practice

2) Two systematic reviews shows increased mortality for beta-carotene, Vitamin A, Vitamin E, but not for selenium and Vitamin C

JAMA 2007;297:842-57

Cochrane Database Syst Rev 2008;(2):CD007176

3) BMI – not too fat and not too skinny

Lancet 2006;368:666–78

J Am Geriatr Soc 2010;58:234–41

4) Vitamin B (folic acid) and homocysteine – 1 positive trial, 3 negative trials

JAMA 2002; 288:973-9

N Engl J Med 2004;350:2673-81

JAMA 2004;291:565-75

J Am Coll Cardiol 2003;41:2105-13

4) Measuring hsCRP—An Important Part of a Comprehensive Risk Profile or a Clinically Redundant Practice?
PLoS Med 2010;7:e1000196

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