In episode 313, James and Mike go over two new large COPD trials that looked at the use of different types of inhalers and find that unfortunately they do very little to clinically relevant outcomes. The bottom line is don’t smoke.
Show notes
1) SUMMIT trial – Fluticasone furoate and vilanterol
2) FLAME trial – Indacaterol–Glycopyrronium versus Salmeterol–Fluticasone for COPD
In episode 312, Mike and James give you PREMIUM information on high dose Vit D, delayed antibiotics, spironolactone and pioglitazone. All this new evidence supports pretty much all the premium stuff we’ve been saying for years – thank goodness.
Show notes
1) Vitamin D
JAMA Intern Med 2016;176:175-83
2) Delayed antibiotics
3) Spironolactone
4) Pioglitazone
In episode 311, Mike and James finish off the series on back pain by looking at the best available evidence around treatment options. We look at the evidence behind acetaminophen, NSAIDs, cyclobenzaprine, narcotics, antidepressants, spinal manipulation, injections, massage, ice, heat, and the kitchen sink.
Show notes
In episode 310, Mike and James continue looking at the evidence around back pain and focus on imaging. Unnecessary early imaging not only does nothing but makes things worse. Explaining things to patients seems to be as successful as imaging. When it comes to appropriate imaging red flags are key. At the end of the podcast Mike and James end up waving a white flag in frustration with the evidence.
Show notes
See previous podcast
In episode 309, Mike and James set-off on a series of podcasts looking at the evidence around back pain from a diagnosis, imaging and treatment perspective. In this podcast we talk about issues associated with pain studies and start to look at the evidence around imaging. At the end we realise this entire area is a pain that emanates from a place just a bit lower than the back.
Show notes
In episode 308, James and Mike go over the HOPE-3 trial results in hopefully a hopeful way and we hope that people will appreciate the review. At the end we hope that nobody does any more statin trials ever again but we aren’t to hopeful about that possibility.
Show notes
1) HOPE-3 trials
Statin
Blood pressure
2) HOPE-3 results on mystudies.org
HOPE-3
In episode 307, Mike and James engage Tina in yet another discussion and this time it is all about using lower doses of isotretinoin in the treatment of acne. Yet again, James’ approach to using lower doses wins the day and Mike and Tina bow in deference to James’ omnipotence – at least they do in his dreams.
Show notes
1) Tools For Practice
In episode 306, Mike and James engage Tina in a discussion on the first medication approved specifically for female sexual dysfunction. She titillates us with the FDA approval stories and the evidence behind the use of this agent.
Show note
1) Tools For Practice
Flibanserin: Feeling frisky or falling over?
2) Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-Analysis
JAMA Intern Med. 2016 Feb 29. doi: 10.1001/jamainternmed.2015.8565
In episode 305, Mike and James continue to simply describe the Simplified Lipid Guidelines developed by the Alberta gang last year. And it’s as simple as that.
Show notes
Simplified lipid guidelines – Prevention and management of cardiovascular disease in primary care
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
