Episode 275: Worrying about anxiety

In episode 275, James and Mike anxiously enlist Adrienne Lindblad to help us with deciphering the literature surrounding anxiety medications. We discuss the issue of anxiety scales in the studies, and look at the evidence around the use of antidepressants and antipsychotics for GAD.

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Episode 274: Two new drugs that follow all our rules

In episode 274, Mike and James for a change look at the evidence behind two new drugs – one for over active bladder and one for depression and find unfortunately that as usual new drugs are no better than what we already have.

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1) Over active bladder drug

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Episode 273: Osteoarthritis treatments - an inflammatory discussion about the evidence – PART II

In episode 273, Mike and James break down even more evidence around treatments for osteoarthritis. In this episode, we discuss topical NSAIDs, alternative therapies, narcotics and conclude, as in the previous podcast, that it is ultimately up to the patient to try to figure out what works best for them.

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Episode 272: Osteoarthritis treatments - an inflammatory discussion about the evidence

In episode 272, Mike and James break down all the evidence around treatments for osteoarthritis. In this episode, we discuss activity, acetaminophen, NSAIDs and the benefits and harms around these treatments and at the end we come to the conclusion that it is ultimately up to the patient to try to figure out what works best for them.

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Episode 271: PREMIUM – DESCARTES, OSLER, ODYSSEY and what you need to know

In episode 271, James and Mike discuss the most recent evidence for two new monoclonal antibody medications that lower lipids. We discuss the two new studies OSLER and ODYSSEY. At the end we both agree that it is great these studies looked at cardiovascular events and at least they are going in the right direction. However, we still have a long way to go before we would consider using them. Read more »

Episode 270: Antivirals for the flu – something to sneeze about

In episode 270, the Mikes and Tina and James stay viral, and discuss the best available evidence around the use of antiviral medications for treatment of the flu. At the end, we all agree there is an effect and that the person who should make the decision should be the patient once they have had the benefits and harms appropriately explained. Read more »

Episode 269: The ins and outs of the HPV vaccine

In episode 269, the Mikes and James go viral on the HPV vaccine. We discuss what the evidence shows around the use of the HPV vaccine in females and males and in contrast to many people, we actually present the numbers so that you can help people, or help yourself make decisions.

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Episode 268: An agitating podcast on benzo’s for agitation in dementia

In episode 268, Mike and James discuss the use of benzodiazepines in the management of agitation in demented elders. We discuss the evidence and realise that the evidence is at best iffy. Nonetheless, they seem to be as effective as antipsychotics but both classes of drugs have side effects and should be used in low doses and stopped as soon as possible.  Read more »