In episode 213, Mike and James get back to listener questions and we talk about hormones and VTE, gliptins, sulfonlyureas. statins, risk calculators, the elderly and statins and targets. At the end we answer the question “what is the meaning of life” but unfortunately we ran out of tape and this answer wasn’t recorded.

Show notes

1) The ESTHER study

Circulation 2007:115:840-5

2) Gliptins/DPP4s, sulfonlyureas

SAVOR-TIMI 53 – saxagliptin and cardiovascular outcomes

September 2, 2013DOI: 10.1056/NEJMoa1307684 

EXAMINE – alogliptin and cardiovascular outcomes

September 2, 2013DOI: 10.1056/NEJMoa1305889

Sulphonylureas and risk of cardiovascular disease:systematic review and meta-analysis

Diabet Med 2013;30:1160–71

3) Statin intolerance

RxFiles – Statin intolerance – management considerations

4) The greatest CVD risk calculator ever

5) Statins and the elderly

J Am Coll Cardiol 2013;doi:10.1016/j.jacc.2013.07.069

In episode 214, James and Mike notch the discussion up to a PREMIUM level yet again. We discuss the 2 new gliptin studies, SAVOR-TIMI 53 (saxagliptin) and EXAMINE (alogliptin) and we find that low and behold these medications lower glucose and have no impact on cardiovascular disease. At the end we lament this lack of cardiovascular benefit by singing a chorus of “Another One Bites The Dust”.

Show notes

1) SAVOR-TIMI 53 – saxagliptin and cardiovascular outcomes

September 2, 2013DOI: 10.1056/NEJMoa1307684 

2) EXAMINE – alogliptin and cardiovascular outcomes

September 2, 2013DOI: 10.1056/NEJMoa1305889

In episode 213, James and Mike continue on their merry quest of answering the world’s problems. We discuss CRP, ibuprofen for pain, zoster vaccines, thiazides and risk calculators. The questions are answered so well that at the very end Mike and James also solve world hunger and the Middle East crisis.

Show notes 

1) CRP measurements

PLoS Med 7(2):e1000196.doi:10.1371/journal.pmed.1000196

2) Ibuprofen dosing

NEJM 1991;325:87-91

3) 200 vs 400 mg of ibuprofen for headaches

Headache 2001;41:665-79

4) Zoster vaccine

Tools for practice

Zoster vaccine: Zoster loster or imposter coster?

5) Thiazides reduce blood pressure in patients with severe
renal disease

Ann Pharmacother 2012;46:1554-8

6) The greatest CVD risk calculator ever

In episode 212, Mike and James get back into the saddle by jumping into a gamish of listener questions. We perfectly discuss triglycerides, pancreatitis, risk calculators, antibiotics and everything else that is of upmost importance to all health care professionals across the world. At the end James and Mike get counseling for delusions of grandeur.

Show notes 

1) Lipid-modifying therapies and risk of pancreatitis: a meta-analysis

JAMA 2012;308:804-11

2) The “BEST” Risk Calculator ever 🙂

http://bestsciencemedicine.com/chd

Agreement among cardiovascular disease risk calculators

Circulation 2013;127:1948-56

3) Antibiotic stewardship

Aminoglycoside use and monitoring

Clin
Inf Dis 1992;14:320-39

Pharmacotherapy 2000;20:1524-7

Aminoglycoside combinations

BMJ 2004;328:668

Clin Infect Dis. (2013)doi: 10.1093/cid/cit223

4) A prescription for improving antibiotic prescribing in primary care

BMJ 2012;344:d7955

5) Viva La Evidence – a parody of Coldplay’s Viva La Vida – it’s all about evidence-based healthcare – a little bit about the history of evidence and then the key principles.

http://youtu.be/QUW0Q8tXVUc