In episode 283, Mike and James discuss the latest T2DM study showing that sitagliptin at least doesn’t cause much harm. We then veer off to discuss everything you need to know about diastolic and systolic blood pressure and how are they associated with CVD. Finally we discuss an n-of-1 study looking at statin-related myalgia. Bottom line – this was clearly a PREMIUM podcast.

Show notes

1) TECOS – Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

N Engl J Med 2015; 373:232-242

2) Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

Lancet 2014;383:1899-1911

3) N-of-1 (Single-Patient) Trials for Statin-Related Myalgia

Ann Intern Med 2014;160:301-310

In episode 282, James and the Mikes discuss the use of digoxin for systolic heart failure and atrial fibrillation. At the end we realize that if people would just use low doses and occasionally re-evaluate they would get into a lot less trouble with digoxin and maybe a few patients would benefit.

Show notes

1) Tools for Practice

Digoxin: Old friend or best left on the shelf?

2) Evidence Network

evidencenetwork.ca

In episode 281, James and Mike welcome back our friend and colleague Bruce Arroll to talk about a great study he and his colleagues recently completed looking at simple bedtime restriction for the treatment of primary insomnia – and the results were pretty impressive. So much so that Bruce had to wake us both up at the end of the podcast.

Show notes

1) Development, validation (diagnostic accuracy) and audit of the Auckland Sleep Questionnaire: a new tool for diagnosing causes of sleep disorders in primary care

2) A double-blind randomised controlled study of a brief intervention of bedtime restriction for adult patients with primary insomnia 

In episode 280, James and Mike continue on with Jon Ference about information mastery. Jon talks about hunting and foraging tools and how you can access tools that will work best for your practice. And at the end we all go out and hunt and forage and have a delicious evidence-based meal.

Show notes

Information Mastery Handout