In episode 398, James and Mike continue their discussion of the evidence around the class of agents called monoclonal antibodies. In this podcast we focus on medications that have an effect on symptoms and at the end we put the entire class into perspective – at least as much as we can.
Show notes
In episode 397, James and Mike discuss the evidence around the class of medications called monoclonal antibodies. We talk a little bit about them as a whole and then talk specifically about 6 different agents and the trials that have looked at the effectiveness of these interesting new medications. We come to the conclusion that you need to treat these agents, just like any new medication, by looking at the best available evidence.
Show notes
In episode 396, Mike and James present PREMIUM information from a premium province (BC). We discuss new studies that looked at measurements of blood pressure and bone density. At the end we put all of this information into a premium perspective.
Show notes
Tools for Practice
1) Association of Repeated Measurements With Blood Pressure Control in Primary Care
JAMA Internal Medicine 2018;178:858-60
2) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial
In episode 395, James and Mike bring in Adrienne to chew and digest all the evidence around the ketogenic diet. At the end we realize we will likely never have definitive evidence around these diet issues so we all commiserate by drowning our sorrows in a large helping of deep fried Mars Bars.
Show notes
Tools for Practice
Less Pancakes, More Bacon? The Ketogenic Diet for Weight Loss
In episode 394, James and Mike bring in Tina and Joey to look at all the evidence around omega-3 supplements and dry eye and, despite widespread use, the evidence is far from convincing.
Show notes
Tools for Practice
Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch?
In episode 393, James and Mike bring in Tina to deal with the issue of the evidence around CPAP. We find out that there is little evidence that CPAP reduces CVD so it is all about does the person feel better while on it – over and above the nuisance and cost.
Show notes
Tools for Practice
In episode 392, James and Mike get back to work after a European tour and other reasons. We go over the results from the latest large aspirin trials and, low and behold, the results show pretty much what we already knew.
Show notes
1) Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial.
Lancet 2018 Aug 24. pii: S0140-6736
2) Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
N Engl J Med. 2018 Aug 26. doi: 10.1056/NEJMoa1804988
3) The best CVD risk calculator
In episode 391, Mike and James have yet again a PREMIUM moment that will leave you short of breath. We go over 2 new studies that looked at asthma action plans and does increasing doses of inhaled corticosteroids work. In the last study we go over a comparison of vaginal estradiol, vaginal moisturizer or placebo for perimenopausal vulvovaginal symptoms, and placebo ends up working as well as anything else.
Show notes
1) Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
2) Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations
3) Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms
In episode 390, James and Mike have a discussion about how a shared-decision may be the only real outcome to measure if one is doing, or evaluating, evidence-based practice. Do our arguments convince you? Have we missed something important? Is this the best podcast ever on shared-decision making? Do you think we should be locked up? We would love feedback.
Show notes
Shared decision is the only outcome that matters when it comes to evaluating evidence-based practice
In episode 389, Mike and James go over with Adrienne Lindblad the evidence for a simple treatment for beast engorgement. Who knew that cabbage leaves worked for breast engorgement? At the end of the podcast we decide to attach cabbage leaves to all our microphones all the time, just in case – see last podcast description for context.
Show notes
Tools for Practice
Is that cabbage in your bra? Cabbage leaves for breast engorgement
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
