In episode 415, Mike and James continue with an overview of the evidence around depression. In this episode we talk about the use of antipsychotics for depression or augmentation of antidepressants, stopping antidepressants and the chances of withdrawal, and non-medication treatments.
Show notes
In episode 414, Mike and James continue with an overview of the evidence around depression. In this episode we talk about antidepressant management nuances from lower doses, to dose escalation, switching, and the time to response.
Show notes
In episode 413, Mike and James continue with an overview of the evidence around depression. In this episode we talk about the evidence around the effectiveness of antidepressants and learn if they work, how well they work, and if any one is better than the others.
Show notes
In episode 412, Mike and James do an overview of the evidence around depression. In this episode we talk about ruling out depression and the struggle of how to look at antidepressant evidence.
Show notes
In episode 411, Mike and James get annoyed – obviously in a nice way – having to talk about a new cohort study on eggs and an RCT of yet another omega-3 product. We try to put them into the context of all the other evidence available for these “products”.
Show notes
1) Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) Study-randomized weight-loss and follow-up phase
Am J Clin Nutr. 2018 Jun 1;107(6):921-931. doi: 10.1093/ajcn/nqy048
2) Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality
JAMA. 2019;321(11):1081-1095. doi:10.1001/jama.2019.1572
3) Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10
In episode 410, Mike, James, and Adrienne discuss the evidence around antidepressants in the elderly. We find 40% to 80% of elderly patients will recover with antidepressants, but a number of studies show no difference from placebo response rates. In addition, approximately 20% will stop due to adverse effects.
Show notes
Tools for Practice
In episode 409, Mike and James yet again welcome Adrienne from Red Deer to talk about whether or not we need to give antibiotics for drained abscesses. We find out that relatively, the benefit of increased cure is similar to the chance of side effects.
Show notes
Tools for Practice
There’s Pus About, So Are Antibiotics In or Out? Adding antibiotics for abscess management
In episode 408, Mike and James talk about a couple of recent survey publications. One, which examined patient satisfaction around patient requests and denials of those requests. The other examined how often and why patients are not always honest about disclosing medically relevant information. At the end we decide there is a little liar in all of us and we just need to accept it.
Show notes
1) Association of clinician denial of patient requests with patient satisfaction
JAMA Intern Med 2018;178:85-91
2) Prevalence of and factors associated with patient nondisclosure of medically relevant information to clinicians
JAMA Network Open. 2018;1(7):e185293. doi:10.1001/jamanetworkopen.2018.5293
3) Register for the Best Science Medicine Course – May3/4, 2019 in Vancouver
In episode 407, Mike and James go PREMIUM and talk about three potentially practice changing trials. Water for recurrent UTIs, e-cigarettes for smoking cessation, and acetaminophen for febrile seizures. It doesn’t get more PREMIUM than that.
Show notes
1) Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections
JAMA Intern Med. doi:10.1001/online October 1, 2018
2) A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy
January 30, 2019 DOI: 10.1056/NEJMoa1808779
3) Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode
In episode 406, Mike, James, and Tina go over the evidence for treating opioid use disorder in primary care and the evidence is clear that it can be done in primary care but specialized opioid treatment programs are also obviously needed.
Show notes
1) Tools for Practice
Location, Location, Location: Treating patients with opioid use disorder in primary care
2) CFPC webinar – 12:00PM EST Feb 12, 2019
Top 10 take-home points for advance care planning in primary care
YouTube link: www.youtube.com/watch?v=-mWsMA39YOw
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)
