In episode 331, James and Mike talk about the ups and downs of erectile dysfunction. We take a penetrating look at the epidemiology and what initial assessments should be done – treatments will pop-up in the next podcast. Fortunately or unfortunately, we rarely raise our comments above what would be expected from 14 year-old boys.
Show notes
In episode 330, Mike and James do a PREMIUM job of looking at 2 important new publications about medications for type 2 diabetes. We look at an RCT of semaglutide that actually shows a benefit. We then look at a very thorough systematic review/meta-analysis of all the studies and publications around T2DM since 1998. The results demonstrate very clearly that the evidence doesn’t really support what is being written in the diabetes clinical practice guidelines.
Show notes
1) SUSTAIN-6
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
N Engl J Med 2016; 375:1834-44
2) Glycemic Control for Patients With Type 2 Diabetes Mellitus Our Evolving Faith in the Face of Evidence
Circ Cardiovasc Qual Outcomes. 2016;9:00-00. DOI: 10.1161/CIRCOUTCOMES.116.002901.
In episode 329, Mike and James continue with their update on the treatment of dementia. We talk about prevention and how to figure out if an individual is getting a benefit from treatment. Bottom line, it is very tricky. We also talk about non-drug treatments and the latest new drug treatment.
Show notes
See Episode 328
In episode 328, Mike and James do an update of what is new for the treatment of dementia. We go over the scales used to assess dementia and then look at the latest trials for the commonly used drugs. Sadly, the treatments are still sorely limited.
Show notes
In episode 327, Mike and James do a delicious podcast around the evidence for chocolate. We look at the cohorts and the RCTs that have looked at the effect of this heavenly food on outcomes like mortality, cardiovascular disease, blood pressure, depression and acne. The results make us happy and smile.
Show notes
In episode 326, Mike (with James just there for his charm) goes over three studies in the area of renal stones, testosterone, and sleep apnea and the outcome, as expected, can be considered nothing but PREMIUM.
Show notes
1) Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial
2) Effects of Testosterone Treatment in Older Men
3) CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea
4) Laughing alongside the best of evidence: Family physicians change ideas about tools, knowledge, practice, and medicine
In episode 325, Mike and James continue their discussion about numbers and how to communicate risks. We discuss if people even want shared decisions and then if they do, what talk tools to use to facilitate that discussion.
Show notes
FRACTURES
If you know BMI – Canadian data from FRAX
If you know BMD – Canadian data from FRAX
Mayo Osteoporosis Decision Aid
CVD
ATRIAL FIBRILLATION
Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence
Circ Cardiovasc Qual Outcomes. 2016 Aug 23. pii: CIRCOUTCOMES.116.002901
In episode 324, Mike and James start a discussion about why numbers and our ability to communicate risks, benefits and harms to patients is crucial in today’s health care environment. Unfortunately, we find that many of us struggle with these concepts.
Show notes
In episode 323, James and Mike go over two new studies that have looked at the risk of using LABAs in combination with inhaled corticosteroids in both adults and children. Bottom line – no increased risk, but also not a lot of benefit either.
Show notes
Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma
Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone
In episode 322, Mike and James go over a new Tools for Practice that looked at the use of a combination product that may reduce the risk of HIV. It definitely seems to work but adherence is the key.
Show notes
Tools for Practice
Pre-Exposure Prophylaxis (PrEP): Are you PrEP’d for the future of HIV prevention?
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)
