Episode 142: Polypharmacy – a pollyanna approach to a polymorphic problem – Part III

In episode 142, Mike and James finish off the elderly, but hopefully not literally, by discussing some key RCTs that help inform us as to a few medications that likely should be part of your discussion/armamentarium with your elderly patients. At the end Mike extols the virtues of low doses and James tells him I told you so.

Show notes

1) “Optimal” managaement of elderly patients with vascular disease

Am Heart J 2006;152:585-92

2) Drug withdrawal in the elderly

IMAJ 2007;9:430–434.

3) Withdrawing antipsychotics

JAMA 2005;294:1934-43

NEJM 2005:353:2335-41

Lancet Neurol 2009;8:151–57

PLoS Med 5(4): e76.doi:10.1371/journal.pmed.0050076

4) Testosterone

NEJM 2010; 363:109-22

5) BP in the elderly

Lancet 2000;355:865–872

Cochrane CD000028

N Engl J Med 2008;358:1887-98

Cardiol J 2009;16:379–385

Hypertens Res 2008;31:1595-601

Hypertension 2010;56:196-202

Circulation 2001;104:1923-6

6) Anticoagulation in the elderly

Lancet 2007;370:493–503

7) Rate control in the elderly with A fib

N Engl J Med 2010;362:1363-73

8) Low-dose iron

Am J Med 2005;118:1142-7