TEC: Evidence Based Therapeutics
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Medication Mythbusters – Home of the Best Science (BS) Medicine Podcast

Episode 143: A heads-up look at the prevention of headaches

In episode 143, Mike and James quickly create headaches among their listeners but fortunately just as quickly get to a discussion about the prevention of headaches with antidepressants. We find out that tricyclics work but SSRIs don’t. To prove that point we both take high doses of fluoxetine during the podcast with no effect, except the clear effect it has on the quality of the podcast. 

Show notes

Tricyclics for preventing headaches

BMJ 2010;341:c5222doi:10.1136/bmj.c5222.2

SSRIs for preventing headaches

Cochrane Library CD002919

Prophylaxis of migraine review

CMAJ 2010;182:E269-76

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