Episode 29: Creating Confusion or Clarity: Q&A of Listener Mail Part II
In Episode 29, we review questions around informed decision-making, risk-benefits of statins across different populations (women, chronic kidney disease, etc), and comparisons of calculated risks and trial results. We also talk about prescribing of new antimicrobials, differentiating typical from atypical pneumonias and then attempt to clarify a few trials including HOPE. James desperately searches for pearls among Mike’s explanations of the uncertainty and gaps in the research.
1) The HOPE trial
2) HOPE was actually more like a blood pressure trial than originally thought – 24 hour blood pressure differences between the 2 groups were 10/4 mmHg
4) Meta-analysis of statins in patients with chronic kidney disease
5) Meta-analysis CMAJ on high vs low dose statin in secondary prevention
6) Mediterranean diet – no difference between the groups in weight, cholesterol or blood pressure at the end of the study but cardiovascular events were reduced
7) ACCORD and ADVANCE trials
8)UKPDS (recent results)
9) BP trial for patients over age 80
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