Episode 384: Talking about personalized medicine with Tim Caulfield

In episode 384, James and Mike invite Tim Caulfield (author, professor and lawyer) to talk about the marketing of personalized medicine. We find out that most of the marketing is absurd. We also figure out that personalized medicine is being done all the time but it rarely if ever requires knowledge of any genetic testing results.

1) Is Gwenyth Paltrow wrong about everything?

2) A user’s guide to cheating death

3) Shattuck lecture–medical and societal consequences of the Human Genome Project

N Engl J Med 1999;341:28-37

4) Representing a “revolution”: how the popular press has portrayed personalized medicine

Genet Med 2018 Jan 4. doi: 10.1038/gim.2017.217

5) Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial

Diabetes Care 2013 Jan;36(1):13-9. doi: 10.2337/dc12-0884

6) Genetic determinants of common obesity and their value in prediction.

Best Pract Res Clin Endocrinol Metab. 2012 Apr;26(2):211-26. doi: 10.1016/j.beem.2011.11.003.

7) Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis

Tob Control 2012 May;21(3):347-54. doi: 10.1136/tc.2011.042739

8) Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial

Clin Gastroenterol Hepatol. 2015 Sep;13(9):1625-1632.e1. doi: 10.1016/j.cgh.2015.02.044

9) Gene Environment Risk Assessment and Colorectal Cancer Screening in an Average Risk Population: A Randomized, Controlled Trial

Ann Intern Med. 2014 Oct 21; 161(8): 537–545.

10) Lifestyle Advice Combined with Personalized Estimates of Genetic or Phenotypic Risk of Type 2 Diabetes, and Objectively Measured Physical Activity: A Randomized Controlled Trial

PLoS Med. 2016 Nov 29;13(11):e1002185. doi: 10.1371/journal.pmed.1002185. eCollection 2016 Nov

11) Born Fat: The Relations Between Weight Changeability Beliefs and Health Behaviors and Physical Health

Health Educ Behav. 2016 Jun;43(3):337-46. doi: 10.1177/1090198115602266. Epub 2015 Sep 8

12) The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis

BMJ. 2016 Mar 15;352:i1102. doi: 10.1136/bmj.i1102

13) Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

PLoS Med. 2014 May 20;11(5):e1001647. doi: 10.1371/journal.pmed.1001647. eCollection 2014 May

14) Why Are Some Population Interventions for Diet and Obesity More Equitable and Effective Than Others? The Role of Individual Agency

PLoS Med. 2016 Apr 5;13(4):e1001990. doi: 10.1371/journal.pmed.1001990. eCollection 2016 Apr