In episode 501, Mike and James get back to being PREMIUM by talking about the impressive effect of Kangaroo care – listen to find out what that is. We also talk about the problem with guidelines around Vitamin D and yet again more evidence for delayed antibiotics.

Show Notes

1) Kangaroo mother care to reduce morbidity and mortality in low birthweight infants
Cochrane Database Syst Rev 2016 Aug 23;2016(8):CD002771
2) Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight
N Engl J Med 2021;384:2028-38
3) Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors
Int J Clin Pract. 2021 Nov;75(11):e14805. doi: 10.1111/ijcp.14805. Epub 2021 Sep 15
4) Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial
Pediatrics. 2021 Mar;147(3):e20201323. doi: 10.1542/peds.2020-1323. Epub 2021 Feb 11.
5) Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis
BMJ 2021;373:n808

James and Mike celebrate their 500th, YIKES, podcast episode. You get to hear the entire intro song (Some People) written and recorded by Pete McCormack. We talk about the history of the podcast, thank a lot of people, and talk about the key messages and the philosophy we have tried to impart over the years. We then discuss a few cases that bring all these ideas into focus. THANKS SO MUCH FOR LISTENING and going on this journey with us. We have had a blast.

Show Notes

Pete McCormack’s Website
Tools for Practice
PEER Evidence

In episode 499, James and Mike invite Tina back again to discuss the evidence we have for dieting to lose weight and the impact of that on osteoarthritis knee pain. Overall, there isn’t a lot of evidence but some observational data suggests a benefit Unfortunately the relatively small weight loss achieved from most diets in RCTs did not demonstrate a difference on OA pain.

Show Notes

Tools for Practice
No Gain, No Pain? – What is the effect of diet-induced weight loss on osteoarthritis-related knee pain?

In episode 498, James and Mike invite Tina back yet again to talk about all the evidence we have for using compression stockings in patients with chronic lower limb edema. The NNT for recurrent cellulitis is pretty good (listen to find out the actual number) on the “NNT scale”.

Show Notes

Tools for Practice
Under Pressure: Compression stockings for recurrent cellulitis?

In episode 497, James and Mike decide to go all in on the evidence around nutrition. We start out by going over how we try to actually figure out if a food is beneficial or harmful for you. And for nutrition is it ever tricky.

Show Notes

The Nutrition Proposition – Coming Soon – I hope

In episode 496, Mike and James continue the discussion with Ricky around the best available evidence we have for heart failure patients with preserved ejection fraction. Unfortunately, not much works but at least you’ll know the evidence. 

Show Notes

In episode 495, Mike and James invite Ricky back again to talk about the options (not a lot) we have for heart failure patients with preserved ejection fraction. Ricky goes over all the trials and helps put them into context.

Show Notes

In episode 494, Mike and James invite Ricky Turgeon to talk about a potential new use for an old drug – colchicine. Ricky explains all the evidence we have for low-dose colchicine in people with a history of cardiovascular disease. We find out that colchicine reduces the risk of a cardiovascular event in a similar magnitude to statins – but will they be used as much as statins.? Find out what we think.

Show Notes

Tools for Practice

Cardiovascular prevention trials: Now calling colchicine to the stand

In episode 493, Mike and James review all the Long COVID data. We talk about how many people get it, what the symptoms are and how long it can persist – and it can be a long time. COVID long-term is different than what we see with the regular flu.

Show Notes

Tools for Practice

Long COVID: A (somewhat) short summary of risks, symptoms, and natural course

In episode 492, Mike and James delve into a couple of potentially practice-changing results. The first trial looked at the effect of different shoes for knee osteoarthritis. You might be surprised by the results. The second trial is the first ever look at a salt substitute and what it does, believe it or not, to cardiovascular events and death. Yeah! You might also be surprised by the results. Check out what was found in this PREMIUM podcast.

Show Notes

1) The Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms: A Randomized Trial

Ann Intern Med. 2021 Apr 174:462-71

2) Effect of Salt Substitution on Cardiovascular Events and Death

N Engl J Med 2021; 385:1067-1077 DOI: 10.1056/NEJMoa2105675