In episode 263, Mike and James finally get back to the whole podcasting thing and answer a bunch of great listener questions. We leave it to the listeners to decide if our answers are of a similar great calibre.
Show notes
1) Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department
In episode 262, Tina, Mike and James discuss the ins and outs of their new BMJ paper on televised medical talk shows. TMJ and the gang did a thorough investigation of the recommendations made by two nationally televised medical talk shows (The Dr Oz Show and The Doctors). We looked at what specifically these shows recommended and what was the evidence behind these recommendations – in other words how believable were their recommendations. Have a listen, go read the paper and you’ll be armed with the best available evidence around the recommendations made by these shows.
Show notes
The BMJ article
In episode 261, Mike and James finish examining the evidence surrounding the periodic health exam. We discuss the don’t do’s when it comes to test ordering and screening. At the end James congratulates Mike on the great job he did with this podcast trilogy and this shocks Mike so much he suggests James come in for an extensive periodic health exam.
Show notes
In episode 260, Mike and James continue examining the evidence surrounding the periodic health exam. We discuss the dos and maybe nots and the whats we should be doing around test ordering and screening. At the end we realise we probably do more than we really should and that is important for us and our patients to be aware of the benefits and harms of what we do.
Show Notes
In episode 259, Mike and James start off a potential podcast trilogy on the evidence surrounding the periodic health exam. We start off by talking about what patient’s want, what do doctor’s think, the harms of screening and the overall evidence for the periodic health exam. At the end we realise the elements of the PHE need to be examined in detail so stay tuned.
Show notes
Episode 258: IMPROVE-IT – ezetimibe, what it does and doesn’t do
In episode 258, James and Mike discuss the very recently released IMPROVE-IT study that was presented November 17th, 2014 at the AHA meeting. We discuss what was found and what wasn’t found and whether or not these results lend credence to the lipid hypothesis. We find that finally a drug used to change a surrogate marker actually appears to reduce cardiovascular events (we have had 20 negative trials in a row before this) but the magnitude is certainly not huge. We discuss the nuances of the results and hopefully put it into a reasonable perspective.
Show notes
In episode 257, Mike and James go PREMIUM yet again and discuss the latest RCTs on Coenzyme Q10 in heart failure, antibiotics in otitis media with effusion, treatment for community acquired pneumonia and steroids for alopecia areata. Bottom line – you don’t want to miss the premium experience.
Show notes
1) The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial
JACC Heart Fail. 2014 Sep 25. pii: S2213-1779
2) Effect of antimicrobial treatment of acute otitis media on the daily disappearance of middle ear effusion: a placebo-controlled trial.
JAMA Pediatr. 2014 Jul;168(7):635-41. doi: 10.1001/jamapediatrics.2013.5311.
3) β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia
JAMA Intern Med. 2014 Oct 6. doi: 10.1001/jamainternmed.2014.4887
4) Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children – A Randomized Clinical Trial
JAMA Dermatol. 2014 Jan;150(1):47-50. doi: 10.1001/jamadermatol.2013.5764
In episode 256, Mike, Mike, and James discuss the evidence around family history when it comes to cardiovascular disease risk estimates. To prove a point, during the podcast the Mikes gang up on James just as if they were siblings and it all ends in tears.
Show notes
1) Tools For Practice
What risks do different family histories of cardiovascular disease (CVD) carry?
In episode 255, Mike and James discuss the evidence around the measurement of lipoproteins and find out that while they are interesting from a research perspective, they are of little if any value in clinical practice. At the end of the podcast Mike gets not only irked but flummoxed and just this is worth the price of admission.
Show notes
1) Tools For Practice
Lipoproteins: The risk of (over)interpreting these risk factors?
In episode 254, James and Mike finish of their dietary podcast buffet. We tackle weight loss and then look at all the best available evidence around overall nutrition and it comes up looking pretty good for the Mediterranean diet – or something similar. We hope at the end of this trilogy on nutrition all our listeners enjoyed each course and that you will stay tuned for more BS Medicine podcasts – or as we refer to them – dessert with a cherry and whipped cream on the top.
Show notes
1) Weight loss
N Engl J Med 2008;359:229-41
Food & Nutrition Research 2012,56:19103
PLOS ONE 2014;9:e100652
Ann Intern Med 2014;161:309-318
JAMA 2014;312:923-33
N Engl J Med 2009;360:859-73
2) RCT of dietary impacts on cardiovascular disease
Lancet 1994;343:1454-9
JAMA 2006;295:629-642, 643-54, 655-66
Lancet 2002;360:1455-61
N Engl J Med 2013; 368:1279-90
CD002137
3) Saturated fats
Am J Clin Nutr 2010;91:535–46
Ann Intern Med 2014;160:398-406
BMJ Open 2014;4:e004487 doi:10.1136/bmjopen-2013-004487
BMJ 2013 Feb 4;346:e8707. doi: 10.1136/bmj.e8707.
4) Red meat
Circulation 2010;121:2271-83
American Journal of Epidemiology 2013DOI: 10.1093/aje/kwt261
5) Sugar
BMJ 2012;345:e7492 doi: 10.1136/bmj.e7492
Circulation 2012;125:1735-41
JAMA Intern Med 2014;174:516-24
6) Overall
Annu Rev Public Health 2014;35:83–103
THE NUTRITION PROPOSITION BOOK
Check it out at nutritionproposition.com and think about picking up a copy on Amazon. All the evidence you ever wanted about nutrition and the only nutrition book that won’t tell you what to eat.
This pragmatic trial is now recruiting in BC. Make a difference and get involved with pragmatic trials (www.pragmatictrials.ca)
